SLU-12091
SLU-12091 is a phosphodiesterase (PDE) inhibitor and the more potent enantiomer of rac-11. SLU-12091 inhibits the activities of hPDE5, hPDE11, hPDE2A1, hPDE3A, hPDE3B, hPDE4A1A and hPDE4D2. SLU-12091 inhibits the growth of Cryptosporidium parvum without inhibiting the growth of host cells at the highest concentration tested. SLU-12091 can be used for the research of cryptosporidiosis.
For research use only. We do not sell to patients.
- CAS No.: 3065124-09-3
- Formula: C23H23BFN5O2
- Molecular Weight:431.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
PDE5 |
PDE11 |
PDE2A |
PDE3A |
PDE3B |
PDE4A1 |
PDE4D2 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-8 | EC50 |
0.011 μM
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Inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion.
Inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion.
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42593902 |
| HCT-8 | EC90 |
0.020 μM
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90% inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion.
90% inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion.
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42593902 |
In Vitro
SLU-12091 (ent2-11) (0.011 μM; 48 h) potently inhibits Cryptosporidium parvum replication in HCT-8 cells with an EC50 of 11 nM and shows no cytotoxicity against HCT-8 cells up to 50 μM[1].
SLU-12091 (0.1-10 μM) inhibits multiple human PDE enzymes, with the strongest activity against hPDE5, hPDE4D2, hPDE3A, hPDE3B, and hPDE2A1 at 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3065124-09-3
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Molecular Weight 431.27
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Formula C23H23BFN5O2
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SMILES
FC1=CC=C(C=C1)CNC2=NC(C3=CC=C4B(O[C@H](C4=C3)C)O)=NC5=C2C(CC)=NN5C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SLU-12091 Related Classifications
HY-189060 Related Classifications
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