Sphingolactone-24
Sphingolactone-24 (Sph-24) is a selective and irreversible neutral sphingomyelinase (nSMase) inhibitor. Sphingolactone-24 has the potential for the research of acute lung injury.
For research use only. We do not sell to patients.
- CAS No.: 881177-99-7
- Formula: C18H29NO4
- Molecular Weight:323.43
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
All Phospholipase Isoforms
More
Biological Activity
Description
In Vitro
Sphingolactone-24 (50 µM; 30 min+24 h) inhibits LPS-induced p38 MAPK phosphorylation and antagonized the antiapoptotic effect LPS (HY-D1056)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
-
Cell Line:human neutrophils
-
Concentration:50 µM
-
Incubation Time:30 min +24 h (30 min before LPS (500 ng/ml) treatment)
-
Result:Inhibited LPS-induced p38 MAPK phosphorylation and antagonized the antiapoptotic effect of LPS.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C3H/HeN breeder mice (LPS 10 mg/kg; intranasal instillation)[1]
-
Dosage:1 mg/kg
-
Administration:I.p.; 3 and 9 h thereafter LPS
-
Result:Improved survival and reduced the severity of LPS-induced acute lung injury (ALI).
Chemical Information
-
CAS No. 881177-99-7
-
Molecular Weight 323.43
-
Formula C18H29NO4
-
SMILES
C/C=C/C=C/C(N[C@H]([C@@]1([H])CC(C(O1)=O)CCCCCC)CO)=O
-
Synonyms
Sph-24
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Inhalation Toxicity Study
Inhalation toxicity studies expose rodents to a controlled aerosol, vapor, gas, or smoke atmosphere and assess respiratory and systemic toxicity using exposure-atmosphere characterization, clinical observations, body and organ weights, bronchoalveolar lavage fluid, histopathology, blood chemistry, hematology, and, when included, molecular endpoints such as transcriptomics, proteomics, lipidomics, or tissue burden analysis. The primary biological readouts are airway irritation, pulmonary inflammation, cytotoxicity, altered surfactant or lipid homeostasis, impaired particle clearance, and tissue remodeling, reflected by BALF cell differentials, BALF protein, LDH, phosphatase activities, cytokines, lung weight, microscopic respiratory-tract lesions, and retained lung burden.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sphingolactone-24 Related Classifications
HY-136994 Related Classifications
Powered by Bioz