Sphingosine (d17:1)
Based on 1 Customer Validation
Sphingosine (d17:1) is a 17-carbon sphingosine found in human skin.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 6918-48-5
- Formula: C17H35NO2
- Molecular Weight:285.47
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Sphingosine (d17:1) can be phosphorylated by sphingosine kinases to produce C-17 sphingosine-1-phosphate. Sphingosine C-17 was used as an internal standard for spectral analysis of sphingoid compounds. Sphingosine (d17:1) is an important bioactive lipid that mediates the cell signaling transduction, exhibits neuroprotective and anti-apoptotic activity[2][3][4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6918-48-5
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Appearance Solid
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Molecular Weight 285.47
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Formula C17H35NO2
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Color White to off-white
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SMILES
OC[C@H](N)[C@H](O)/C=C/CCCCCCCCCCCC
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMF : 10 mg/mL (35.03 mM; Need ultrasonic and warming)
DMSO : ≥ 2 mg/mL (7.01 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Stewart ME, et al. Free sphingosines of human skin include 6-hydroxysphingosine and unusually long-chain dihydrosphingosines. J Invest Dermatol. 1995 Oct;105(4):613-8. [Content Brief]
[2]. Hong JH, et al. K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling. J Invest Dermatol. 2008 Sep;128(9):2166-78. [Content Brief]
[3]. Choi CH, et al. Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development. Arch Pharm Res. 2007 Apr;30(4):502-6. [Content Brief]
[4]. Zeng K, et al., Determination of endogenous sphingolipid content in stroke rats and HT22 cells subjected to oxygen-glucose deprivation by LC‒MS/MS. Lipids Health Dis. 2023 Jan 25;22(1):13. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / DMF | 1 mM | 3.5030 mL | 17.5150 mL | 35.0300 mL | 87.5749 mL |
| 5 mM | 0.7006 mL | 3.5030 mL | 7.0060 mL | 17.5150 mL | |
| DMF | 10 mM | 0.3503 mL | 1.7515 mL | 3.5030 mL | 8.7575 mL |
| 15 mM | 0.2335 mL | 1.1677 mL | 2.3353 mL | 5.8383 mL | |
| 20 mM | 0.1751 mL | 0.8757 mL | 1.7515 mL | 4.3787 mL | |
| 25 mM | 0.1401 mL | 0.7006 mL | 1.4012 mL | 3.5030 mL | |
| 30 mM | 0.1168 mL | 0.5838 mL | 1.1677 mL | 2.9192 mL |
Sphingosine (d17:1) Related Classifications
HY-141579 Related Classifications
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