Sulphadimethoxypyrimidine

Sulphadimethoxypyrimidine (100 mg/kg; p.o.; single dose) administered orally at 100 mg/kg is rapidly excreted in rhesus monkeys, with its N¹-glucuronide accounting for 44% of the 24-hour urinary excretion^[1].
Sulphadimethoxypyrimidine (100 mg/kg; p.o.; single dose) administered orally at 100 mg/kg is rapidly excreted in New Zealand white rabbits, with no detectable N¹-glucuronide formed and unchanged drug accounting for 36% of the 24-hour urinary excretion^[1].
Sulphadimethoxypyrimidine (100 mg/kg; p.o.; single dose) administered orally at 100 mg/kg is slowly excreted in Wistar albino rats, with unchanged drug accounting for 58% of the 24-hour urinary excretion and only 7% consisting of the N¹-glucuronide metabolite^[1].
Sulphadimethoxypyrimidine (100 mg/kg; i.p.; single dose) administered intraperitoneally at 100 mg/kg shows 24-hour urinary excretion of 22% in Wistar albino rats, which is more than three times the excretion seen after oral administration^[1].
Sulphadimethoxypyrimidine (100 mg/kg; i.p.; single dose) administered intraperitoneally at 100 mg/kg is excreted in bile of cannulated Wistar albino rats, with 19.0% of the dose recovered in 24 hours and the N⁴-glucuronide accounting for the majority of biliary metabolites^[1].