1. TGF-beta/Smad
  2. TGF-β Receptor
  3. SY-LB-57

SY-LB-57 is a highly potent bone morphogenetic protein (BMP) receptor signaling agonist. SY-LB-57 can be used in studies of diseases such as fractures and pulmonary arterial hypertension.

For research use only. We do not sell to patients.

SY-LB-57 Chemical Structure

SY-LB-57 Chemical Structure

CAS No. : 2253719-35-4

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10 mg USD 210 In-stock
25 mg USD 420 In-stock
50 mg USD 680 In-stock
100 mg USD 1100 In-stock
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Description

SY-LB-57 is a highly potent bone morphogenetic protein (BMP) receptor signaling agonist. SY-LB-57 can be used in studies of diseases such as fractures and pulmonary arterial hypertension[1].

In Vitro

SY-LB-57 (0.01-1000 μM, 24 h) can significantly induce cell proliferation at concentrations below 10 µM with an IC50 value of 807.93 µM in C2C12 cells[1].
SY-LB-57 (0.01-10 μM, 15-30 min) increases the phosphorylation of Smad protein and promotes p-Smad nuclear translocation while activates the PI3K/Akt pathway and induces cytoplasmic localization of p-Akt[1].
SY-LB-57 (0.01-10 μM, 24 h) can induce cell cycle shift towards proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: C2C12 cells
Concentration: 0.01-1000 μM
Incubation Time: 24 hours
Result: Resulted in 85% reduction in the cell viability of C2C12 at 1 mM while increased cell viability by 280%, 290%, 200%, 150% and 50% at 0.01 µM, 0.1 µM, 1 µM, 10 µM and 100 µM, respectively.

Western Blot Analysis[1]

Cell Line: C2C12 cells
Concentration: 0.01-10 μM
Incubation Time: 15min or 30 min
Result: Significantly increased phosphorylation of Smad protein, 50% to 257% higher compared to control after 30 min.
Showed a significant increase in p-Akt expression levels, exceeding the control by 667-1081% after 15 min.

Cell Cycle Analysis[1]

Cell Line: C2C12 cells
Concentration: 0.01-10 μM
Incubation Time: 24 hours
Result: Resulted in a significant decrease in the percentage of G0/G1 phase cells and a dramatic increase in S and G2/M phase cells.
Molecular Weight

263.29

Formula

C16H13N3O

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

COC1=CC2=C(NC(C3=NC4=CC=CC=C4N3)=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (63.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7981 mL 18.9905 mL 37.9809 mL
5 mM 0.7596 mL 3.7981 mL 7.5962 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7981 mL 18.9905 mL 37.9809 mL 94.9523 mL
5 mM 0.7596 mL 3.7981 mL 7.5962 mL 18.9905 mL
10 mM 0.3798 mL 1.8990 mL 3.7981 mL 9.4952 mL
15 mM 0.2532 mL 1.2660 mL 2.5321 mL 6.3302 mL
20 mM 0.1899 mL 0.9495 mL 1.8990 mL 4.7476 mL
25 mM 0.1519 mL 0.7596 mL 1.5192 mL 3.7981 mL
30 mM 0.1266 mL 0.6330 mL 1.2660 mL 3.1651 mL
40 mM 0.0950 mL 0.4748 mL 0.9495 mL 2.3738 mL
50 mM 0.0760 mL 0.3798 mL 0.7596 mL 1.8990 mL
60 mM 0.0633 mL 0.3165 mL 0.6330 mL 1.5825 mL
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SY-LB-57 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
SY-LB-57
Cat. No.:
HY-150793
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