SY-LB-57
Based on 1 Customer Validation
SY-LB-57 is a highly potent bone morphogenetic protein (BMP) receptor signaling agonist. SY-LB-57 can be used in studies of diseases such as fractures and pulmonary arterial hypertension.
For research use only. We do not sell to patients.
- Purity: 99.66%
- CAS No.: 2253719-35-4
- Formula: C16H13N3O
- Molecular Weight:263.29
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
SY-LB-57 (0.01-1000 μM, 24 h) can significantly induce cell proliferation at concentrations below 10 µM with an IC50 value of 807.93 µM in C2C12 cells[1].
SY-LB-57 (0.01-10 μM, 15-30 min) increases the phosphorylation of Smad protein and promotes p-Smad nuclear translocation while activates the PI3K/Akt pathway and induces cytoplasmic localization of p-Akt[1].
SY-LB-57 (0.01-10 μM, 24 h) can induce cell cycle shift towards proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:C2C12 cells
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Concentration:0.01-1000 μM
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Incubation Time:24 hours
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Result:Resulted in 85% reduction in the cell viability of C2C12 at 1 mM while increased cell viability by 280%, 290%, 200%, 150% and 50% at 0.01 µM, 0.1 µM, 1 µM, 10 µM and 100 µM, respectively.
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Cell Line:C2C12 cells
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Concentration:0.01-10 μM
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Incubation Time:15min or 30 min
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Result:Significantly increased phosphorylation of Smad protein, 50% to 257% higher compared to control after 30 min.
Showed a significant increase in p-Akt expression levels, exceeding the control by 667-1081% after 15 min.
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Cell Line:C2C12 cells
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Concentration:0.01-10 μM
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Incubation Time:24 hours
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Result:Resulted in a significant decrease in the percentage of G0/G1 phase cells and a dramatic increase in S and G2/M phase cells.
Chemical Information
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CAS No. 2253719-35-4
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Appearance Solid
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Molecular Weight 263.29
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Formula C16H13N3O
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Color Off-white to light yellow
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SMILES
COC1=CC2=C(NC(C3=NC4=CC=CC=C4N3)=C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 16.67 mg/mL (63.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7981 mL | 18.9905 mL | 37.9809 mL | 94.9523 mL |
| 5 mM | 0.7596 mL | 3.7981 mL | 7.5962 mL | 18.9905 mL | |
| 10 mM | 0.3798 mL | 1.8990 mL | 3.7981 mL | 9.4952 mL | |
| 15 mM | 0.2532 mL | 1.2660 mL | 2.5321 mL | 6.3302 mL | |
| 20 mM | 0.1899 mL | 0.9495 mL | 1.8990 mL | 4.7476 mL | |
| 25 mM | 0.1519 mL | 0.7596 mL | 1.5192 mL | 3.7981 mL | |
| 30 mM | 0.1266 mL | 0.6330 mL | 1.2660 mL | 3.1651 mL | |
| 40 mM | 0.0950 mL | 0.4748 mL | 0.9495 mL | 2.3738 mL | |
| 50 mM | 0.0760 mL | 0.3798 mL | 0.7596 mL | 1.8990 mL | |
| 60 mM | 0.0633 mL | 0.3165 mL | 0.6330 mL | 1.5825 mL |
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