2. Inhibitory Antibodies
  3. Taldefgrobep alfa

Taldefgrobep alfa  (Synonyms: BMS 986089; RG 6206; RO 7239361)

Cat. No.: HY-P99518 Purity: 98.65%
COA

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Taldefgrobep alfa (BMS 986089; RG 6206; RO 7239361) is a potent inhibitory antibody targeting to human myostatin. Taldefgrobep alfa is a fusion protein composed of a human IgG1-Fc domain and Adnectin domain. Taldefgrobep alfa can be used for spinal muscular atrophy (SMA) research.

For research use only. We do not sell to patients.

Taldefgrobep alfa Chemical Structure

Taldefgrobep alfa Chemical Structure

CAS No. : 1580555-26-5

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Description

Taldefgrobep alfa (BMS 986089; RG 6206; RO 7239361) is a potent inhibitory antibody targeting to human myostatin. Taldefgrobep alfa is a fusion protein composed of a human IgG1-Fc domain and Adnectin domain. Taldefgrobep alfa can be used for spinal muscular atrophy (SMA) research[1][2].

IC50 & Target

Myostatin[1]
In Vivo

Taldefgrobep alfa (2 mg/kg; iv or sc; single dose) has rapid plasma clearance after intravenous administration in mice, but slow absorption (Tmax=24 h) after subcutaneous administration with Cmax=15.4 mg/mL and bioavailability (F)=84%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Taldefgrobep alfa]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.65%

COA (231 KB)

Handling Instructions (2659 KB)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taldefgrobep alfa1580555-26-5BMS 986089 RG 6206 RO 7239361BMS986089BMS-986089RG6206RG 6206RG-6206RO7239361RO 7239361RO-7239361OthersInhibitorinhibitorinhibit

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