2. PROTAC Vitamin D Related/Nuclear Receptor
  3. PROTACs Androgen Receptor
  4. TD-802

TD-802 (Compound 33c) is an androgen receptor (AR) PROTAC degrader with good microsomal stability. TD-802 has good antitumor efficacy in vivo and can be used for metastatic castration-resistant prostate cancer research.

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TD-802

TD-802 화학구조

CAS No. : 2760703-21-5

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TD-802 Related Antibodies

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제품 설명

TD-802 (Compound 33c) is an androgen receptor (AR) PROTAC degrader with good microsomal stability. TD-802 has good antitumor efficacy in vivo and can be used for metastatic castration-resistant prostate cancer research[1].

Cellular Effect
Cell Line Type Value Description References
LNCaP CC50
0.098 μM
Compound: 33c; TD-802
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability after 6 days by CellTiter-Glo assay
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability after 6 days by CellTiter-Glo assay
[PMID: 32961381]
VCaP CC50
0.044 μM
Compound: 33c; TD-802
Antiproliferative activity against human VCaP cells assessed as reduction in cell viability after 6 days by CellTiter-Glo assay
Antiproliferative activity against human VCaP cells assessed as reduction in cell viability after 6 days by CellTiter-Glo assay
[PMID: 32961381]
분자량

957.56

화학식

C52H61ClN10O6
CAS No.
SMILES

CC1([C@@H](C(C)([C@H]1OC2=CC(Cl)=C(C=C2)C#N)C)NC(C3=CC=C(C=C3)N4CCN(CC4)C5CC6(C5)CCN(CC6)C(C7CCN(CC7)C8=CC=C9N=NN(C(C9=C8)=O)C%10CCC(NC%10=O)=O)=O)=O)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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TD-802 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TD-8022760703-21-5TD802TD 802PROTACsAndrogen Receptormicrosomal stabilityproteolysis-targeting chimeraprostate cancerInhibitorinhibitorinhibit

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상품명:
TD-802
Cat. No.:
HY-146397
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