TGF-βRI inhibitor 2
Based on 1 Customer Validation
TGF-βRI inhibitor 2 (compound 13) is a TGF-βRI inhibitor. TGF-βRI inhibitor 2 can be used in cancer research.
For research use only. We do not sell to patients.
- Purity: 98.32%
- CAS No.: 476474-11-0
- Formula: C20H16N4O
- Molecular Weight:328.37
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
0.42 μM
Compound: 13
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Antiproliferative activity against mouse NIH3T3 cells by [3H]thymidine assay
Antiproliferative activity against mouse NIH3T3 cells by [3H]thymidine assay
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[PMID: 18314943] |
| Sf9 | IC50 |
0.16 μM
Compound: 13
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Inhibition of TGFbeta type receptor 1 ALK5 (T204D) expressed in Sf9 cells
Inhibition of TGFbeta type receptor 1 ALK5 (T204D) expressed in Sf9 cells
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[PMID: 18314943] |
Chemical Information
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CAS No. 476474-11-0
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Appearance Solid
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Molecular Weight 328.37
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Formula C20H16N4O
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Color Light yellow to brown
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SMILES
OC1=CC=C2C(C(C(C3=CC=CC=N3)=N4)=C5N4CCC5)=CC=NC2=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 7.14 mg/mL (21.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Li HY, et al. Optimization of a dihydropyrrolopyrazole series of transforming growth factor-beta type I receptor kinase domain inhibitors: discovery of an orally bioavailable transforming growth factor-beta receptor type I inhibitor as antitumor agent. J Med Chem. 2008 Apr 10;51(7):2302-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0453 mL | 15.2267 mL | 30.4535 mL | 76.1336 mL |
| 5 mM | 0.6091 mL | 3.0453 mL | 6.0907 mL | 15.2267 mL | |
| 10 mM | 0.3045 mL | 1.5227 mL | 3.0453 mL | 7.6134 mL | |
| 15 mM | 0.2030 mL | 1.0151 mL | 2.0302 mL | 5.0756 mL | |
| 20 mM | 0.1523 mL | 0.7613 mL | 1.5227 mL | 3.8067 mL |
TGF-βRI inhibitor 2 Related Classifications
HY-W028145 Related Classifications
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