Thioetheramide-PC
Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) is a structurally modified phospholipid that acts as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). Thioetheramide-PC has an IC50 value of 2 μM at a substrate concentration of 0.5 mM. In addition to binding to the catalytic site of sPLA2, Thioetheramide-PC also binds to the activation site of the enzyme. Thioetheramide-PC binds more tightly to the activation site than to the catalytic site. As a result of this dual interaction, at low concentrations, Thioetheramide-PC may activate phospholipase activity rather than inhibit it.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 116457-99-9
- Formula: C40H83N2O5PS
- Molecular Weight:735.14
-
Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-13402
VarespladibsPLA2 Inhibitor -
HY-100736
ML348APT1/LYPLA1 Inhibitor -
HY-19619
m-3M3FBSPhospholipase C Activator -
HY-120441
CAY10590sPLA2 Inhibitor -
HY-107411
Bromoenol lactonePhospholipase Inhibitor -
HY-115062
MJ33 lithium saltPLA2 Inhibitor -
HY-123070
ONO-RS-082PLA2 Inhibitor -
HY-101293
VU0359595PLD1 Inhibitor -
HY-107393
LY-311727sPLA2 Inhibitor -
HY-108612
VU0155069PLD1 Selective Inhibitor -
HY-108608
o-3M3FBSActive Compound -
HY-108607
PACOCF3Phospholipase A2 Inhibitor
Biological Activity
Description
Chemical Information
-
CAS No. 116457-99-9
-
Appearance Liquid
-
Molecular Weight 735.14
-
Formula C40H83N2O5PS
-
Color Colorless to light yellow
-
SMILES
CCCCCCCCCCCCCCCCSC[C@@H](NC(CCCCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O
-
Synonyms
1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Solution, -20°C, 2 years
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
-
Data Sheet (260 KB)
-
SDS (545 KB)
- English - EN (545 KB)
- Français - FR (545 KB)
- Deutsch - DE (545 KB)
- Norwegian - NO (545 KB)
- Español - ES (545 KB)
- Swedish - SV (545 KB)
- Italian - IT (545 KB)
- Korean - KR (545 KB)
- Portuguese - PT (545 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thioetheramide-PC Related Classifications
HY-133233 Related Classifications
Powered by Bioz