2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. TNKS 22

TNKS 22 (compound 22) is an orally active and selective tankyrase inhibitor. TNKS 22 inhibits TNKS1 and TNKS2 with IC50s of 0.1 and 4.1 nM, respectively.

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TNKS 22

TNKS 22 Chemical Structure

CAS No. : 1507362-00-6

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TNKS 22 Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

TNKS 22 (compound 22) is an orally active and selective tankyrase inhibitor. TNKS 22 inhibits TNKS1 and TNKS2 with IC50s of 0.1 and 4.1 nM, respectively[1].

Cellular Effect
Cell Line Type Value Description References
DLD-1 IC50
0.6 nM
Compound: 22
Inhibition of TNKS in human DLD1 cells expressing APC mutant assessed as inhibition of super-Topflash reporter gene transcription after 40 to 48 hrs by dual-glo luciferase reporter gene assay
Inhibition of TNKS in human DLD1 cells expressing APC mutant assessed as inhibition of super-Topflash reporter gene transcription after 40 to 48 hrs by dual-glo luciferase reporter gene assay
[PMID: 24294969]
SW480 EC50
3.9 nM
Compound: 22
Inhibition of TNKS in human SW480 cells assessed as accumulation of axin-2 into cytoplasmic foci after 24 hrs by Hoechst dye-based assay
Inhibition of TNKS in human SW480 cells assessed as accumulation of axin-2 into cytoplasmic foci after 24 hrs by Hoechst dye-based assay
[PMID: 24294969]
SW480 IC50
0.004 μM
Compound: 22
Inhibition of TNKS in human SW480 cells assessed as degradation of total pool of beta-catenin after 40 to 48 hrs
Inhibition of TNKS in human SW480 cells assessed as degradation of total pool of beta-catenin after 40 to 48 hrs
[PMID: 24294969]
Masse moléculaire

475.56

Formule

C25H25N5O3S
CAS No.
SMILES

O=C1C2=CC=CC=C2NC(SCCC(N[C@@H]3CC[C@@H](C4=NN=C(C5=CC=CC=C5)O4)CC3)=O)=N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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TNKS 22 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNKS 221507362-00-6TNKS-IN-22TNKS22TNKS-22PARPpoly ADP ribose polymerasetankyraseTNKS1TNKS2Inhibitorinhibitorinhibit

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HY-12601
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