Toddacoumaquinone
Toddacoumaquinone is a coumarin-naphthoquinone dimer found in the roots of Toddalia asiatica. Toddacoumaquinone inhibits acetylcholinesterase (AChE) and β-amyloid (Aβ1-42) aggregation, with an IC50 of 46 μM against electric eel acetylcholinesterase. Toddacoumaquinone exerts antiviral effects against herpes simplex virus type 1 and herpes simplex virus type 2 (HSV). Toddacoumaquinone is used in research related to Alzheimer's disease and herpesvirus infections.
For research use only. We do not sell to patients.
- CAS No.: 142878-03-3
- Formula: C23H18O7
- Molecular Weight:406.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
electric eel AChE 46 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Vero | EC50 |
9.80 μg/mL
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Inhibition of herpes simplex virus type 1 (strain KOS) plaque formation in Vero cell monolayers by plaque reduction assay after 1 to 2 d incubation at 37°C.
Inhibition of herpes simplex virus type 1 (strain KOS) plaque formation in Vero cell monolayers by plaque reduction assay after 1 to 2 d incubation at 37°C.
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7641303 |
| Vero | EC50 |
10.0 μg/mL
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Inhibition of herpes simplex virus type 2 (strain 186) plaque formation in Vero cell monolayers by plaque reduction assay after 1 to 2 d incubation at 37°C.
Inhibition of herpes simplex virus type 2 (strain 186) plaque formation in Vero cell monolayers by plaque reduction assay after 1 to 2 d incubation at 37°C.
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7641303 |
In Vitro
Toddacoumaquinone inhibits acetylcholinesterase (IC50 = 46 μM), AChE-induced Aβ1-42 aggregation (IC50 = 72 μM), and self-induced Aβ1-42 aggregation (IC50 = 145 μM)[1].
Toddacoumaquinone (compound 1) exhibits weak antiviral activity against HSV-1 (EC50 = 9.80 μg/mL) and HSV-2 (EC50 = 10.0 μg/mL) in the Vero cell plaque reduction assay, and shows no activity against HIV-1 at concentrations up to 10 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 142878-03-3
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Molecular Weight 406.39
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Formula C23H18O7
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SMILES
O=C1OC2=C(C=C1)C(OC)=CC(OC)=C2C3=CC(=CC=4C(=O)C=C(OC)C(=O)C43)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Toddacoumaquinone Related Classifications
HY-N21596 Related Classifications
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Keywords
- Toddacoumaquinone
- 142878-03-3
- Cholinesterase (ChE)
- Amyloid-β
- amyloid beta peptide
- herpes simplex virus type 1
- acetylcholinesterase
- catalytic anionic site
- Alzheimer's disease
- peripheral anionic site
- herpes simplex virus type 2
- human immunodeficiency virus type 1
- Vero cell
- Electrophorus electricus
- Inhibitor
- inhibitor
- inhibit