Toddacoumaquinone
Toddacoumaquinone is a coumarin-naphthoquinone dimer found in the roots of Toddalia asiatica. Toddacoumaquinone inhibits acetylcholinesterase (AChE) and β-amyloid (Aβ1-42) aggregation, with an IC50 of 46 μM against electric eel acetylcholinesterase. Toddacoumaquinone exerts antiviral effects against herpes simplex virus type 1 and herpes simplex virus type 2 (HSV). Toddacoumaquinone is used in research related to Alzheimer's disease and herpesvirus infections.
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- CAS. Nr.: 142878-03-3
- Formel: C23H18O7
- Molecular Weight:406.39
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
electric eel AChE 46 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Vero | EC50 |
9.80 μg/mL
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Inhibition of herpes simplex virus type 1 (strain KOS) plaque formation in Vero cell monolayers by plaque reduction assay after 1 to 2 d incubation at 37°C.
Inhibition of herpes simplex virus type 1 (strain KOS) plaque formation in Vero cell monolayers by plaque reduction assay after 1 to 2 d incubation at 37°C.
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7641303 |
| Vero | EC50 |
10.0 μg/mL
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Inhibition of herpes simplex virus type 2 (strain 186) plaque formation in Vero cell monolayers by plaque reduction assay after 1 to 2 d incubation at 37°C.
Inhibition of herpes simplex virus type 2 (strain 186) plaque formation in Vero cell monolayers by plaque reduction assay after 1 to 2 d incubation at 37°C.
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7641303 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 142878-03-3
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Molecular Weight 406.39
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Formel C23H18O7
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SMILES
O=C1OC2=C(C=C1)C(OC)=CC(OC)=C2C3=CC(=CC=4C(=O)C=C(OC)C(=O)C43)C
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Takomthong P, et al. Structure-Activity Analysis and Molecular Docking Studies of Coumarins from Toddalia asiatica as Multifunctional Agents for Alzheimer's Disease. Biomedicines. 2020 May 2;8(5):107. [Content Brief]
[2]. Ishikawa T, et al. Synthesis of toddacoumaquinone, a coumarin-naphthoquinone dimer, and its antiviral activities. Chemical & pharmaceutical bulletin. 1995 Jun;43(6):1039-41. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Toddacoumaquinone Related Classifications
HY-N21596 Related Classifications
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Keywords
- Toddacoumaquinone
- 142878-03-3
- Cholinesterase (ChE)
- Amyloid-β
- amyloid beta peptide
- herpes simplex virus type 1
- acetylcholinesterase
- catalytic anionic site
- Alzheimer's disease
- peripheral anionic site
- herpes simplex virus type 2
- human immunodeficiency virus type 1
- Vero cell
- Electrophorus electricus
- Inhibitor
- inhibitor
- inhibit