2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase I inhibitor 12

Topoisomerase I inhibitor 12 (compound 12), a Camptothecin (HY-16560)-based derivative, is a potent Topoisomerase I inhibitor. Topoisomerase I inhibitor 12 shows anticancer activity.

For research use only. We do not sell to patients.

Topoisomerase I inhibitor 12

Topoisomerase I inhibitor 12 Chemical Structure

CAS No. : 3038811-66-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Topoisomerase I inhibitor 12 Related Antibodies

Top Publications Citing Use of Products

View All Topoisomerase Isoform Specific Products:

View All Isoforms
Topoisomerase Topo I Topo II DNA gyrase

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Topoisomerase I inhibitor 12 (compound 12), a Camptothecin (HY-16560)-based derivative, is a potent Topoisomerase I inhibitor. Topoisomerase I inhibitor 12 shows anticancer activity[1].

IC50 & Target

Topoisomerase I

 

Cellular Effect
Cell Line Type Value Description References
BJ IC50
4.25 μM
Compound: 12
Cytotoxicity against human BJ cells incubated for 48 hrs by MTT assay
Cytotoxicity against human BJ cells incubated for 48 hrs by MTT assay
[PMID: 38185054]
DU-145 IC50
3.81 μM
Compound: 12
Cytotoxicity against human DU-145 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human DU-145 cells incubated for 48 hrs by MTT assay
[PMID: 38185054]
HCT-116 IC50
3.67 μM
Compound: 12
Cytotoxicity against human HCT-116 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells incubated for 48 hrs by MTT assay
[PMID: 38185054]
HOS IC50
1.47 μM
Compound: 12
Cytotoxicity against human HOS cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HOS cells incubated for 48 hrs by MTT assay
[PMID: 38185054]
MCF7 IC50
56.4 μM
Compound: 12
Cytotoxicity against human MCF7 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells incubated for 48 hrs by MTT assay
[PMID: 38185054]
MDA-MB-231 IC50
5.96 μM
Compound: 12
Cytotoxicity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
[PMID: 38185054]
MG-63 IC50
17.94 μM
Compound: 12
Cytotoxicity against human MG-63 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human MG-63 cells incubated for 48 hrs by MTT assay
[PMID: 38185054]
PANC-1 IC50
19.05 μM
Compound: 12
Cytotoxicity against human PANC-1 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human PANC-1 cells incubated for 48 hrs by MTT assay
[PMID: 38185054]
PC-3 IC50
> 100 μM
Compound: 12
Cytotoxicity against human PC-3 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human PC-3 cells incubated for 48 hrs by MTT assay
[PMID: 38185054]
SAOS-2 IC50
3.2 μM
Compound: 12
Cytotoxicity against human SAOS-2 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human SAOS-2 cells incubated for 48 hrs by MTT assay
[PMID: 38185054]
SK-OV-3 IC50
3.48 μM
Compound: 12
Cytotoxicity against human SK-OV-3 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human SK-OV-3 cells incubated for 48 hrs by MTT assay
[PMID: 38185054]
In Vitro

Topoisomerase I inhibitor 12 (compound 12) shows moderate antiproliferative activity against the MDA-MB-231, DU-145, HCT-116, SKOV-3, and SAOS-2 cancer cell lines (with IC50 values of 5.96±0.03, 3.81±1.37, 3.67±0.21, 3.48±1.02, and 3.20±0.21 µM, respectively), as well as potent activity against the HOS (osteosarcoma) cancer cell line (IC50=1.47 µM) while the potential of Topoisomerase I inhibitor 12 against fibroblast normal cells (BJ1) demonstrated a 2.89-fold selectivity (IC50=4.25 µM) against cancer cell[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase I inhibitor 12 Related Antibodies
Molecular Weight

402.45

Formula

C23H22N4O3
CAS No.
SMILES

O=C1N2C(N(CCN3CCOCC3)C(/C2=C\C4=CC=CC=C4)=O)=NC5=CC=CC=C51
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Topoisomerase I inhibitor 12 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase I inhibitor 123038811-66-1Topoisomerase I inhibitor12Topoisomerase I inhibitor-12TopoisomeraseMDA-MB-231DU-145HCT-116SKOV-3SAOS-2HOSosteosarcomaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Topoisomerase I inhibitor 12
Cat. No.:
HY-161082
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.