(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol X-114
Based on 2 publication(s) in Google Scholar
(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol X-114 is a surfactant. (1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol X-114 is used to solubilize membranes and whole cells. A solution of (1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol X-114 is homogeneous at 0 degrees C but separates in an aqueous phase and a detergent phase above 20 degrees C. (1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol X-114 can be used in phase separation studies.
For research use only. We do not sell to patients.
- Purity: 99.5%
- CAS No.: 9036-19-5
- Formula: (C2H4O)nC14H22O
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol X-114
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Biological Activity
(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol X-114 (4%) is added to induce phase separation through cycles of cooling and heating[1].
A solution of (1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol X-114 is homogeneous at 0 degrees C but separates in an aqueous phase and a detergent phase above 20 degrees C[2].
(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol X-114 is used to solubilize membranes and whole cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9036-19-5
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Appearance Liquid (Density: 1.06 g/cm3)
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Formula (C2H4O)nC14H22O
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Color Colorless to light yellow
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SMILES
OCCO[2H].CC(C)(C)CC(C)(C)C.C1=CC=CC=C1.[n].[1].[1]
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Synonyms
Polyoxyethylene octylphenol ether
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Cancer Cell
2025 Jul 17:S1535-6108(25)00273-9. PMID: 40712567 -
J Control Release
Bioswitchable intracellular delivery of small activating RNA by tetrahedral framework nucleic acid: Application to p21-mediated anti-tumor therapy. [Abstract]2025 Nov 30:389:114488. PMID: 41330514
Solvent & Solubility
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (560 KB)
- English - EN (560 KB)
- Français - FR (560 KB)
- Deutsch - DE (560 KB)
- Norwegian - NO (560 KB)
- Español - ES (560 KB)
- Swedish - SV (560 KB)
- Italian - IT (560 KB)
- Korean - KR (560 KB)
- Portuguese - PT (560 KB)
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Handling Instructions (2659 KB)
References
[1]. Wu ZY, et al. Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors. Cancer Cell. 2025 Sep 8;43(9):1714-1730.e12. [Content Brief]
[2]. Bordier C. Phase separation of integral membrane proteins in Triton X-114 solution. J Biol Chem. 1981 Feb 25;256(4):1604-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol X-114 Related Classifications
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