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Cat. No.: HY-P992169

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ABS-101

ABS-101 is a humanized monoclonal antibody that targets TL1A. It binds to both TL1A monomers and trimers and functions as a CD3xTROP2 T-cell engager. By blocking the TL1A/DR3 axis, ABS-101 alleviates inflammatory bowel disease (IBD) and can be used in research related to IBD.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (257 KB)

ABS-101 Chemical Structure

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Stock

Quantity

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Species Reactivity
- In Vitro
- Gene ID
- Accession
- Target
- Conjugated
- Reconstitution
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Species Reactivity

Human

In Vitro

ABS-101 shows reduced internalization of TL1A immune-complexes in THP-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Gene ID

9966 [NCBI]

Accession

O95150

Target

TL1A/TNFSF15

Conjugated

Unconjugated

Reconstitution

The product can be reconstituted/diluted with sterile PBS or saline.

Application

ELISA, FACS, Functional assay

Chemical Information

Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (257 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Philippidis A. Absci Advances Lead AI-Designed Candidate for IBD into the Clinic. GEN Edge. 2025 May 28;7(1):genedge-7.

[2]. Zhou Y, et al. 1155 ABS-101, a novel class of tumor-activated CD3xTROP2 T cell engager for solid tumors[J]. 2024.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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