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Cat. No.: HY-119958

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Acamelin

Acamelin is a Benzofuranoquinone compound that acts as a contact sensitizer. It can be isolated from the heartwood of Acacia melanoxylon R. Br., an Australian blackwood. Acamelin induces positive skin reactions and contact allergy in guinea pigs. It is applicable to research related to allergic contact dermatitis.

For research use only. We do not sell to patients.

CAS No.: 74161-27-6
Formula: C₁₀H₈O₄
Molecular Weight:192.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Acamelin Chemical Structure

CAS No.: 74161-27-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
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Biological Activity

Description

In Vivo

Acamelin (1% concentration; epicutaneous; single application) acts as a contact sensitizer in sensitized Pirbright white-strain guinea pigs, eliciting positive skin reactions in all tested animals, with slightly stronger and longer-lasting responses than 2,6-Dimethoxy-1,4-benzoquinone (HY-N1677)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Pirbright white-strain (female, allergic contact dermatitis model)^[1]
Dosage:

1% concentration
Administration:

epicutaneous; single application
Result:

Elicited ++ skin reaction in 2 of 5 guinea pigs, + reaction in 2, and (+) reaction in 1 at 24 hours post-challenge.
Elicited ++ skin reaction in 2 of 5 guinea pigs, + reaction in 2, and (+) reaction in 1 at 48 hours post-challenge.
Induced slightly stronger and longer-lasting skin reactions than co-isolated 2,6-dimethoxy-1,4-benzoquinone.

Chemical Information

CAS No. 74161-27-6
Appearance Solid
Molecular Weight 192.17
Formula C₁₀H₈O₄
SMILES

O=C(C=C(C1=O)OC)C2=C1OC(C)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hausen BM, et al. Quinonoid constituents as contact sensitisers in Australian blackwood (Acacia melanoxylon RBR). British journal of industrial medicine. 1981 May;38(2):105-9.

[2]. McKittrick B A, et al. A simple synthesis of the natural benzofuranoquinone, acamelin[J]. Journal of the Chemical Society, Perkin Transactions 1, 1983, 12: 2423-2424.

[3]. Schmalle H W, et al. Acamelin, A new sensitizing furano-quinone from Acacia melanoxylon R. BR[J]. Tetrahedron Letters, 1980, 21(2): 149-152.

[4]. Mann J, et al. Rearrangements of aryl-8-oxabicyclo [3.2. 1] octenones: synthesis of novel biaryls and 1-aryl-3-furylpropanones[J]. Journal of the Chemical Society, Chemical Communications, 1985, 21(21): 1543-1544.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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