B-355252
Based on 1 publication(s) in Google Scholar
B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD).
For research use only. We do not sell to patients.
- Purity: 99.71%
- CAS No.: 1261576-81-1
- Formula: C25H24ClN3O3S2
- Molecular Weight:514.06
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Anti-Parkinson's Disease Compound Library
HY-L085
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Neurodegenerative Disease-related Compound Library
HY-L086
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Antidepressant Compound Library
HY-L108
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Heterocyclic Compound Library
HY-L138
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) B-355252
More
Biological Activity
Chemical Information
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CAS No. 1261576-81-1
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Appearance Solid
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Molecular Weight 514.06
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Formula C25H24ClN3O3S2
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Color White to off-white
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SMILES
O=S(C1=CC(Cl)=C(S1)OC2=CC=CC(N3CCNCC3)=C2)(NCC4=C5C=CC=CC5=CC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Commun Biol
CCAAT/enhancer binding protein beta (C/EBPβ) regulates the formation of the ovarian reserve. [Abstract]2025 Sep 30;8(1):1394. PMID: 41028284
Solvent & Solubility
DMSO : 30 mg/mL (58.36 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (421 KB)
- English - EN (421 KB)
- Français - FR (421 KB)
- Deutsch - DE (421 KB)
- Norwegian - NO (421 KB)
- Español - ES (421 KB)
- Swedish - SV (421 KB)
- Italian - IT (421 KB)
- Portuguese - PT (421 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9453 mL | 9.7265 mL | 19.4530 mL | 48.6325 mL |
| 5 mM | 0.3891 mL | 1.9453 mL | 3.8906 mL | 9.7265 mL | |
| 10 mM | 0.1945 mL | 0.9726 mL | 1.9453 mL | 4.8632 mL | |
| 15 mM | 0.1297 mL | 0.6484 mL | 1.2969 mL | 3.2422 mL | |
| 20 mM | 0.0973 mL | 0.4863 mL | 0.9726 mL | 2.4316 mL | |
| 25 mM | 0.0778 mL | 0.3891 mL | 0.7781 mL | 1.9453 mL | |
| 30 mM | 0.0648 mL | 0.3242 mL | 0.6484 mL | 1.6211 mL | |
| 40 mM | 0.0486 mL | 0.2432 mL | 0.4863 mL | 1.2158 mL | |
| 50 mM | 0.0389 mL | 0.1945 mL | 0.3891 mL | 0.9726 mL |
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