Blosozumab
Based on 1 Customer Validation
Blosozumab (LY2541546) is an anti-Human sclerostin (SOST) antibody inhibitor. Blosozumab stimulates bone formation and reduces bone resorption. Blosozumab can be used in the research of Osteoporosis.
For research use only. We do not sell to patients.
- Purity: 99.45%
- CAS No.: 1132758-87-2
- Molecular Weight:144.88 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG4 kappa
Human
SOST/Sclerostin
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats [2]
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Dosage:1, 10, and 100 mg/kg
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Administration:Intravenous injection (i.v.), once every 3 days (5-week study) or once weekly (6-month study)
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Result:Observed the bone anabolic effects.
Showed significant bleeding and morbidity at 100 mg/kg.
Decreases in the numbers of platelets.
Increased number of bone marrow megakaryocytes at 100 mg/kg.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG4 kappa
ELISA, FACS, Functional assay
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Immobilized SOST Protein, Human (HEK293, His, HY-P70756) can bind Blosozumab. The EC50 for this effect is 42.23 ng/mL.
Chemical Information
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CAS No. 1132758-87-2
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Appearance Liquid
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Molecular Weight 144.88 kDa
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Color Colorless to light yellow
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SMILES
[Blosozumab]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Robert R Recker, et al. A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density. J Bone Miner Res. 2015 Feb;30(2):216-24. [Content Brief]
[2]. Daniel G Rudmann, et al. Rat-specific decreases in platelet count caused by a humanized monoclonal antibody against sclerostin. Toxicol Sci. 2012 Feb;125(2):586-94. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Blosozumab Related Classifications
HY-P99186 Related Classifications
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