Guvacine
Based on 1 publication(s) in Google Scholar
Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 498-96-4
- Formula: C6H9NO2
- Molecular Weight:127.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Guvacine
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Biological Activity
Description
IC50 & Target
IC50: 39 μM (rat GAT-1), 58 μM (rat GAT-2), 378 μM (rat GAT-3), 14 μM (human GAT-1), 119 μM (huam GAT-3) and 1870 μM (human BGT-3)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
14 μM
Compound: 3
|
Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysis
Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysis
|
[PMID: 23336362] |
| HEK293 | IC50 |
114.8 μM
Compound: 21
|
Inhibition of mouse GAT3 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
Inhibition of mouse GAT3 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
|
[PMID: 26706177] |
| HEK293 | IC50 |
20.9 μM
Compound: 21
|
Inhibition of mouse GAT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
Inhibition of mouse GAT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
|
[PMID: 26706177] |
| HEK293 | IC50 |
72.4 μM
Compound: 21
|
Inhibition of mouse GAT2 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
Inhibition of mouse GAT2 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
|
[PMID: 26706177] |
| HEK293 | IC50 |
>1000 μM
Compound: 21
|
Inhibition of mouse BGT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
Inhibition of mouse BGT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting
|
[PMID: 26706177] |
Chemical Information
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CAS No. 498-96-4
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Molecular Weight 127.14
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Formula C6H9NO2
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SMILES
O=C(C1=CCCNC1)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Commun Biol
RBAP48 facilitates the oral squamous cell carcinoma process in an androgen receptor-dependent and independent manners. [Abstract]2025 May 30;8(1):829. PMID: 40442479
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)