OAT-2068
OAT-2068 is a selective, high activity and orally active inhibitor of mouse chitotriosidase (mCHIT1) (IC50=29 nM) and displays 143-fold selectivity over m AMCase (IC50=4170 nM). OAT-2068 displays a good pharmacokinetic profile and is an ideal tool to study the role of CHIT1 in biological systems, including animal models of human diseases.
For research use only. We do not sell to patients.
- CAS No.: 2221950-65-6
- Formula: C23H36ClN7
- Molecular Weight:446.03
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
IC50: 29 nM (mCHIT1); 4200 nM (mAMCase)IC50: 67 nM (hCHIT1); 1300 nM (hAMCase)[2]
In Vitro
OAT-2068 is a potent inhibitor developed for mAMCase (IC50=4200 nM) and mCHIT1(IC50=29 nM), which also displays activity toward hAMCase (IC50=67 nM) and hCHIT1 (IC50=1300 nM), it exhibits off-target activity toward the human ether-a-go-go-related gene (hERG)(hERG IC50=2.4 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2221950-65-6
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Molecular Weight 446.03
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Formula C23H36ClN7
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SMILES
NC1=NNC(N2CCC(N3[C@@H](CC4=CC=C(Cl)C=C4)CN(CC(C)C)[C@@H](C)C3)CC2)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Marzena Mazur, et al. Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase. Bioorg Med Chem Lett. 2018 Feb 1;28(3):310-314. [Content Brief]
[2]. Gleb Andryianau, et al. Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase. ACS Med Chem Lett [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OAT-2068 Related Classifications
HY-125279 Related Classifications
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