URAT1 inhibitor 4
URAT1 inhibitor 4, a Lesinurad derivative, is a potent and orally active URAT1 inhibitor with an IC50 of 7.56 μM. URAT1 inhibitor 4 has higher in vivo urate-lowering efficacy than Lesinurad (HY-15258).
For research use only. We do not sell to patients.
- CAS No.: 2700292-02-8
- Formula: C27H20BrN3O4S3
- Molecular Weight:626.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 7.56 ± 0.52 μM (URAT1), 55.96 ± 10.38 μM (GLUT9)[1]
In Vitro
URAT1 inhibitor 4 (compound 10) inhibits URAT1 and GLUT9 with IC50s of 7.56 ± 0.52 μM and 55.96 ± 10.38 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
URAT1 inhibitor 4 (1000 mg/kg; i.g.; single dosage) exhibits higher survival rate than Lesinurad in mice acute toxicity assessment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming mice (acute hyperuricemia model)[1]
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Dosage:2 mg/kg
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Administration:p.o.; single dosage
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Result:Decreased serum uric acid with an decrease ratio of 73.29%.
Chemical Information
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CAS No. 2700292-02-8
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Molecular Weight 626.56
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Formula C27H20BrN3O4S3
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SMILES
O=C(NS(=O)(C1=CC=C(C=C1)Br)=O)CSC2=NC3=C(C(N2C4=CC=C(C5=C4C=CC=C5)C6CC6)=O)C=CS3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
URAT1 inhibitor 4 Related Classifications
HY-152033 Related Classifications
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