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Cat. No.: HY-W778574

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BAPTA tetracesium

36 Cited Publications

Customer Review

Based on 36 publication(s) in Google Scholar

BAPTA tetracesium is a selective and cell-impermeant chelator for calcium. BAPTA tetracesium has high selectivity against magnesium and calcium. BAPTA tetracesium can also inhibit phospholipase C activity independently of their role as Ca²⁺ chelators.

For research use only. We do not sell to patients.

CAS No.: 480436-84-8
Formula: C₂₂H₂₀Cs₄N₂O₁₀
Molecular Weight:1004.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BAPTA tetracesium Chemical Structure

CAS No.: 480436-84-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (36)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PLC

All Phospholipase Isoforms :

In Vitro

BAPTA tetracesium is widely used as an intracellular buffer to investigate the effects caused by Ca²⁺ release from intracellular calcium stores or Ca²⁺ influx via Ca²⁺-permeable channels in the plasma membrane^[1].
BAPTA tetracesium can be introduced into cells via methods such as patch-clamp and microinjection^[1].
BAPTA tetracesium inhibits PLC activity in isolated Drosophila melanogaster photoreceptor cells with an IC₅₀ of approximately 8 mM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 480436-84-8
Molecular Weight 1004.02
Formula C₂₂H₂₀Cs₄N₂O₁₀
SMILES

O=C(O[Cs])CN(CC(O[Cs])=O)C1=C(OCCOC2=C(N(CC(O[Cs])=O)CC(O[Cs])=O)C=CC=C2)C=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (36)

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Journal Impact Factor

Mil Med Res

Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways. [Abstract]

2023 Nov 25;10(1):56. PMID: 38001521

BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]

BAPTA (10 μmol/L, 24 h). qRT-PCR was used to assess the mRNA level of Il6, Tnfα and Tgfβ3 in HMs.

BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]

BAPTA (10 μmol/L, 24 h). TGF-β1 and IL-6 level in the supernatant of HMs were detected by ELISA.

BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]

BAPTA (10 μmol/L, 24 h). The expression and location of TNF-α in HMs was assessed by confocal microscopy (c). Scale bar = 20 μm.
Sci Immunol

ATP release drives heightened immune responses associated with hypertension. [Abstract]

2019 Jun 28;4(36):eaau6426. PMID: 31253642
Adv Sci (Weinh)

Calcium-Collagen Coupling is Vital for Biomineralization Schedule. [Abstract]

2021 Aug;8(15):e2100363. PMID: 34047068
J Clin Invest

Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer. [Abstract]

2024 Apr 25;134(12):e176355. PMID: 38662435
J Neuroinflammation

P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage. [Abstract]

2025 Aug 28;22(1):208. PMID: 40877894

BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]

BAPTA (10 μM). WB results showed that BAPTA could attenuate the Hb-induced decrease in LAMP1 and m-CTSD/pro-CTSD.

BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]

IF results showed that BAPTA (10 μM) can partially increase the co-localization coefficients of LAMP1 and CTSD.
Environ Chem Ecotoxicol

2025 Nov 19;8:267-280.
Free Radic Biol Med

Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes. [Abstract]

2024 Mar:213:150-163. PMID: 38190923
Sci Total Environ

Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons. [Abstract]

2020 Feb 10;703:134702. PMID: 31753492
Biomed Pharmacother

Barasertib impedes chondrocyte senescence and alleviates osteoarthritis by mitigating the destabilization of heterochromatin induced by AURKB. [Abstract]

2023 Oct:166:115343. PMID: 37634474
Biomed Pharmacother

Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm. [Abstract]

2023 May:161:114480. PMID: 37002575
Cell Death Discov

2026 May 25. PMID: 42185253
Cell Rep

Aryl hydrocarbon receptor-induced activation of AIM2 inflammasome is mediated by MOMP and MPT: A vital therapeutic pathway for inflammation. [Abstract]

2025 Dec 10;44(12):116673. PMID: 41385364
J Pineal Res

Sleep Deprivation Induces Gut Damage via Ferroptosis. [Abstract]

2024 Aug;76(5):e12987. PMID: 38975671
J Invest Dermatol

TRPV3-Activated PARP1/AIFM1/MIF Axis through Oxidative Stress Contributes to Atopic Dermatitis. [Abstract]

2024 May 30:S0022-202X(24)00384-1. PMID: 38823435
J Ginseng Res

Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice. [Abstract]

2022 Jul;46(4):515-525. PMID: 35818419
J Ethnopharmacol

Ginsenoside Rg1 attenuates T2DM-induced renal damage and fibrosis by inhibiting TRPC6-ChREBP-TXNIP signaling. [Abstract]

2025 Apr 29:348:119863. PMID: 40311716
J Ethnopharmacol

Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36/TRPC6/NFAT2 signaling in type 2 diabetes mellitus mice. [Abstract]

2023 Feb 10;302(Pt A):115923. PMID: 36375645
Int J Pharm

Reversible increased basement membrane permeability and calcium ion redistribution facilitate ultrasound-enhanced transdermal drug delivery efficiency. [Abstract]

2025 Nov 10:684:126125. PMID: 40914558
J Thromb Haemost

Piezo1 initiates platelet hyperreactivity and accelerates thrombosis in hypertension. [Abstract]

2021 Dec;19(12):3113-3125. PMID: 34411418
Int J Mol Sci

Gut Microbiota-Derived Propionic Acid Mediates ApoA-I-Induced Amelioration of MASLD via Activation of GPR43-Ca2+-CAMKII-ATGL Hepatic Lipolysis. [Abstract]

2026 Jan 1;27(1):468. PMID: 41516340
Int Immunopharmacol

Piezo1 activates Wnt5a/FZD4 signaling to promote osteogenesis and mitigates age-associated bone loss. [Abstract]

2026 Mar 1:172:116168. PMID: 41529412
Toxicology

Nonivamide inhibits proliferation of human corneal epithelial cells by inducing cell cycle arrest and oxidative stress. [Abstract]

2023 Dec:500:153674. PMID: 37989449
Biochim Biophys Acta Mol Basis Dis

Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis. [Abstract]

2025 Jul 18;1871(8):167990. PMID: 40684959
Exp Neurol

Trpc6 knockout improves behavioral dysfunction and reduces Aβ production by inhibiting CN-NFAT1 signaling in T2DM mice. [Abstract]

2023 May:363:114350. PMID: 36791875
J Cell Mol Med

Calpain-2 plays a pivotal role in the inhibitory effects of propofol against TNF-α-induced autophagy in mouse hippocampal neurons. [Abstract]

2020 Aug;24(16):9287-9299. PMID: 32627970
J Funct Foods

2024 Oct.
J Funct Foods

December 2021, 104791.
Aging

Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans. [Abstract]

2019 Nov 22;11(22):10385-10408. PMID: 31757933
Mol Med Rep

Trpc6 knockout protects against renal fibrosis by restraining the CN‑NFAT2 signaling pathway in T2DM mice. [Abstract]

2024 Jan;29(1):13. PMID: 38038121
Cardiovasc Ther

KCa3.1 Promotes Proinflammatory Exosome Secretion by Activating AKT/Rab27a in Atrial Myocytes during Rapid Pacing. [Abstract]

2023 Mar 30:2023:3939360. PMID: 37035755
J Pharm Pharmacol

Fructose aggravates copper-deficiency-induced cardiac remodeling by inhibiting SERCA2a. [Abstract]

2024 May 3;76(5):567-578. PMID: 38271051
J Cancer

JS-K activates G2/M checkpoints through the DNA damage response and induces autophagy via CAMKKβ/AMPKα/mTOR pathway in bladder cancer cells. [Abstract]

2024 Jan 1;15(2):343-355. PMID: 38169515
Vet Microbiol

S100A9 regulates porcine reproductive and respiratory syndrome virus replication by interacting with the viral nucleocapsid protein. [Abstract]

2019 Dec;239:108498. PMID: 31767072
Toxicon

Transient receptor potential canonical 6 is critical for chronic lipopolysaccharide exposure-induced pulmonary injury and fibrosis. [Abstract]

2026 Jun 15:276:109072. PMID: 41850440
Res Sq

2025 Apr 18.
bioRxiv

2023 Jun 25.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tsien RY, et al. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 1980;19(11):2396-2404. [Content Brief]

[2]. Hardie RC. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium. 2005 Dec;38(6):547-56. [Content Brief]

[3]. Collatz MB, et al. Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium. 1997;21(6):453-459. [Content Brief]

Calculators

Molarity Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

BAPTA tetracesium

36 Cited Publications

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (36)
Purity & Documentation
References

1/16
1/16

BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]

Customer Validation
BAPTA (10 μM). WB results showed that BAPTA could attenuate the Hb-induced decrease in LAMP1 and m-CTSD/pro-CTSD.
1/16

BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]

Customer Validation
IF results showed that BAPTA (10 μM) can partially increase the co-localization coefficients of LAMP1 and CTSD.
1/16

BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]

Customer Validation
BAPTA (10 μmol/L, 24 h). qRT-PCR was used to assess the mRNA level of Il6, Tnfα and Tgfβ3 in HMs.
1/16

BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]

Customer Validation
BAPTA (10 μmol/L, 24 h). TGF-β1 and IL-6 level in the supernatant of HMs were detected by ELISA.
1/16

BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]

Customer Validation
BAPTA (10 μmol/L, 24 h). The expression and location of TNF-α in HMs was assessed by confocal microscopy (c). Scale bar = 20 μm.

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BAPTA tetracesium

Publications Citing Use of MedChemExpress (MCE) BAPTA tetracesium

All Phospholipase Isoforms

Biological Activity

Chemical Information

Publications (36)

Purity & Documentation

References

Calculators

Help & FAQs

BAPTA tetracesium Related Classifications

HY-W778574 Related Classifications