CASP10 - caspase 10 Gene

Also Known as MCH4; ALPS2; FLICE2; FLICE-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 843

About CASP10

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:201,183,141-201,229,406 (from NCBI)

This gene has 15 transcripts (splice variants), 192 orthologues, 16 paralogues and is associated with 5 phenotypes. Broad expression in duodenum (RPKM 6.6), spleen (RPKM 5.9) and 23 other tissues.

Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by Caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric Cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

CASP10 Products (12)

mRNA	Protein	Name
NM_001230.5	NP_001221.2	caspase-10 isoform 3 preproprotein
XR_923043.3
NM_001206524.2	NP_001193453.1	caspase-10 isoform 6 preproprotein
XR_923044.3
XM_005246907.3	XP_005246964.1	caspase-10 isoform X1
NM_001306083.2	NP_001293012.1	caspase-10 isoform 7
XM_047446016.1	XP_047301972.1	caspase-10 isoform X2
NM_001206542.2	NP_001193471.1	caspase-10 isoform 5 preproprotein
NM_032976.4	NP_116758.1	caspase-10 isoform 4
XR_007082551.1
NM_032977.4	NP_116759.2	caspase-10 isoform 1 preproprotein
NM_032974.5	NP_116756.2	caspase-10 isoform 2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	16920334	GOA
enables cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16916640	GOA
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	11717445	GOA
enables death effector domain binding	IPI IPI: Inferred from physical interaction	11717445	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12884866	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	15069192	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	12884866	GOA
involved in protein maturation	IDA IDA: Inferred from direct assay	16916640	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CD95 death-inducing signaling complex	IDA IDA: Inferred from direct assay	11717445	GOA
part of ripoptosome	IDA IDA: Inferred from direct assay	21737330	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASP10 Protein Structure

DED

Peptidase_C14

0
100
200
300
400
521 a.a.

Protein Preferred Names	Protein Names
caspase-10	CASP-10 FADD-like ICE2 FAS-associated death domain protein interleukin-1B-converting enzyme 2 ICE-like apoptotic protease 4 apoptotic protease MCH-4 caspase 10 apoptosis-related cysteine peptidase caspase 10, apoptosis-related cysteine protease interleukin-1B-converting enzyme 2

CASP10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CASP10	Q92851	RIOK3	Homo sapiens	O14730	Y2H	21988832
Intra	CASP10	Q92851	RIOK3	Homo sapiens	O14730	Pull Down	21988832
Intra	CASP10	Q92851	RIOK3	Homo sapiens	O14730	Confocal	21988832
Intra	CASP10	Q92851	RIOK3	Homo sapiens	O14730	Anti Bait CoIP	19557502
Intra	CASP10	Q92851	RIPK1	Homo sapiens	Q13546	Pull Down	12884866
Intra	CASP10	Q92851	CFLAR	Homo sapiens	O15519	PLA	25241761
Intra	CASP10	Q92851	CFLAR	Homo sapiens	O15519	Anti Tag CoIP	12887920
Intra	CASP10	Q92851	XIAP	Homo sapiens	P98170	Y2H Prey Pooling	25416956
Intra	CASP10	Q92851	CASP8	Homo sapiens	Q14790	Anti Tag CoIP	12887920
Intra	CASP10	Q92851	CASP8	Homo sapiens	Q14790	FRET	11717445

Cross: Cross-species interaction Intra: Intraspecies interaction

CASP10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80044	Caspase-10 Antibody (YA559)	WB, IHC-P, FC, IP	Human
HY-P82621	Caspase-10 Antibody (YA2366)	WB, IHC-P, IP	Human
HY-P82621A	Caspase-10 Antibody (YA2366)(PBS only)	WB, IHC-P, IP	Human

Related Diseases

Diseases	Alias
Hypersensitivity Reaction Type Iv Disease	Immunoproliferative Disorders Immunoproliferative Disease
Immunodeficiency 60	Bach2-Related Immunodeficiency And Autoimmunity Brida Imd60
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoproliferative Syndrome	Lymphoproliferative Disorder Lymphoproliferative Disorders Lymphoproliferative Disorders, Susceptibility To
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib
Clubfoot	Congenital Clubfoot Congenital Equinovarus Congenital Talipes Equinovarus Equinovarus Deformity Of Foot Club Foot
Autoimmune Lymphoproliferative Syndrome, Type Iii	ALPS3 Autoimmune Lymphoproliferative Syndrome Type 3 Cvid9 Immunodeficiency, Common Variable, 9, Formerly Cvid9, Formerly Autoimmune Lymphoproliferative Syndrome Type Iii Common Variable Immunodeficiency 9 Autoimmune Lymphoproliferative Syndrome 3 Immunodeficiency, Common Variable, 9 Type 3 Autoimmune Lymphoproliferative Syndrome Immunodeficiency, Variable, Common, Type 9
Ras-Associated Autoimmune Leukoproliferative Disorder	RALD Autoimmune Lymphoproliferative Syndrome Type 4 Alps4 Autoimmune Lymphoproliferative Syndrome, Type Iv Ras-Associated Autoimmune Leukoproliferative Disease Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic Alps Type 4 Alps Type Iv Autoimmune Lymphoproliferative Syndrome Type Iv Autoimmune Lymphoproliferative Syndrome 4
Autoimmune Lymphoproliferative Syndrome, Type Iia	Autoimmune Lymphoproliferative Syndrome, Type Ii Autoimmune Lymphoproliferative Syndrome Type 2a ALPS2A Alps2 Autoimmune Lymphoproliferative Syndrome Type Iia Autoimmune Lymphoproliferative Syndrome 2a
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Caspase 8 Deficiency	Autoimmune Lymphoproliferative Syndrome Type 2b Ceds Alps2b Caspase-8 Deficiency Autoimmune Lymphoproliferative Syndrome, Type Iib Alps With Recurrent Viral Infections Autoimmune Lymphoproliferative Syndrome With Recurrent Viral Infections Caspase 8 Deficiency Syndrome Autoimmune Lymphoproliferative Syndrome Type Iib Caspase Eight Deficiency State CASP8D
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-180948	PZ-11	Inducer	/	Unkown
HY-P11596	NOTA-Asp2-αvβ6L		/	Unkown
HY-RS01944	CASP10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown