Semax acetate
Based on 1 publication(s) in Google Scholar
Semax acetate is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax acetate is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax acetate has immunomodulatory, nootropic and neuroprotective activities. Semax acetate can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia.
For research use only. We do not sell to patients.
- Purity: 99.39%
- CAS No.: 2828433-33-4
- Formula: C39H55N9O12S
- Molecular Weight:873.97
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Semax acetate
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Biological Activity
Semax (25-100 μM, 48 h) acetate can reduce the levels of Aβ oligomers[1].
Semax (100 nM) acetate can increase the survival rate of cholinergic neurons in the basal forebrain and stimulate the activity of choline acetyltransferase in cultured basal forebrain tissue ex vivo[2].
Semax (10 μM, 0-4 h) acetate can increase the levels of BDNF and NGF in glial cells derived from the basal forebrain of newborn rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Glial cell cultures from rat basal forebrain
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Concentration:10 μM
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Incubation Time:0.5, 1, 2, 3, 4, 8, 16 and 24 h
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Result:Increased the mRNA levels of BDNF and NGF.
Semax (0.15 mg/kg; intraperitoneal injection; single dose) acetate can increase the concentration of 5-HIAA in the hypothalamus and striatum of mice[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ischemia (pMCAO) rats[4]
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Dosage:100 μg/kg
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Administration:Intraperitoneal injections (i.p.), performed 15 min, 1, 4 and 8 h after permanent middle cerebral artery occlusion (pMCAO).
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Result:Affected the expression of genes related to the immune system. At 3 hours after pMCAO, it influenced the expression of genes regulating the activity of immune cells such as macrophages, neutrophils, and lymphocytes. At 24 hours after pMCAO, the effect on the immune response was significantly increased, with over 50% of the genes with altered expression involved in the immune response.
Affected the expression of genes related to the vascular system. At 3 hours after pMCAO, it influenced genes involved in vasculogenesis, hematopoiesis, and endothelial cell migration. At 24 hours after pMCAO, it affected the development of endothelial tissue, the migration of smooth muscle cells, and the activation of blood cells.
Chemical Information
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CAS No. 2828433-33-4
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Appearance Solid
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Molecular Weight 873.97
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Formula C39H55N9O12S
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Color White to off-white
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Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
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Sequence Shortening
MEHFPGP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 150 mg/mL (171.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Sciacca MFM, et al. Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models. ACS Chem Neurosci. 2022 Feb 16;13(4):486-496. [Content Brief]
[2]. Grivennikov IA, et al. Effects of behaviorally active ACTH (4-10) analogue - Semax on rat basal forebrain cholinergic neurons. Restor Neurol Neurosci. 2008;26(1):35-43. [Content Brief]
[3]. Shadrina MI, et al. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog. Neurosci Lett. 2001 Aug 3;308(2):115-8. [Content Brief]
[4]. Medvedeva EV, et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014 Mar 24;15:228. [Content Brief]
[5]. Eremin KO, et al. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005 Dec;30(12):1493-500. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1442 mL | 5.7210 mL | 11.4420 mL | 28.6051 mL |
| 5 mM | 0.2288 mL | 1.1442 mL | 2.2884 mL | 5.7210 mL | |
| 10 mM | 0.1144 mL | 0.5721 mL | 1.1442 mL | 2.8605 mL | |
| 15 mM | 0.0763 mL | 0.3814 mL | 0.7628 mL | 1.9070 mL | |
| 20 mM | 0.0572 mL | 0.2861 mL | 0.5721 mL | 1.4303 mL | |
| 25 mM | 0.0458 mL | 0.2288 mL | 0.4577 mL | 1.1442 mL | |
| 30 mM | 0.0381 mL | 0.1907 mL | 0.3814 mL | 0.9535 mL | |
| 40 mM | 0.0286 mL | 0.1430 mL | 0.2861 mL | 0.7151 mL | |
| 50 mM | 0.0229 mL | 0.1144 mL | 0.2288 mL | 0.5721 mL | |
| 60 mM | 0.0191 mL | 0.0954 mL | 0.1907 mL | 0.4768 mL | |
| 80 mM | 0.0143 mL | 0.0715 mL | 0.1430 mL | 0.3576 mL | |
| 100 mM | 0.0114 mL | 0.0572 mL | 0.1144 mL | 0.2861 mL |
Semax acetate Related Classifications
HY-P1146A Related Classifications
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