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Cat. No.: HY-184411

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TB-212

TB-212 is a potent, orally active anti-tuberculosis agent. TB-212 exhibits activity against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains, with favorable safety profiles. TB-212 is applicable to the research of tuberculosis.

For research use only. We do not sell to patients.

CAS No.: 3104768-44-4
Formula: C₂₄H₃₀F₃N₅O₄
Molecular Weight:509.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TB-212 Chemical Structure

CAS No.: 3104768-44-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

TB-212 potently inhibits Mycobacterium tuberculosis H37Ra with an MIC₅₀ of 0.2 ng/mL^[1].
TB-212 (Varying concentrations; 72 h) exhibits low cytotoxicity with an IC₅₀ of 19.56 μM against HepG2 cells, IC₅₀ >30 μM against Vero cells, and IC₅₀ >50 μM against A549 cells^[1].
TB-212 (5-45 min) has moderate metabolic stability in human liver microsomes (T_1/2 = 23.71 min) and mouse liver microsomes (T_1/2 = 26.77 min)^[1].
TB-212 potently inhibits Mycobacterium tuberculosis H37Rv (MIC = 4 ng/mL) and drug-resistant clinical isolates (MIC range = 8-32 ng/mL), demonstrating efficacy against both drug-sensitive and drug-resistant strains^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TB-212 (30-150 mg/kg; p.o.; daily; 5 days) exhibits potent in vivo antitubercular activity in BALB/c mice, with the 150 mg/kg daily oral dose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female, 5-6 weeks old)^[1]
Dosage:

30 mg/kg; 150 mg/kg
Administration:

p.o.; daily; 5 days
Result:

Reduced relative light unit (RLU) values compared to the CMCNa negative control at both 30 mg/kg and 150 mg/kg doses.

Chemical Information

CAS No. 3104768-44-4
Molecular Weight 509.52
Formula C₂₄H₃₀F₃N₅O₄
SMILES

FC(F)(F)OC1=CC=C(C=C1)CN(CC2)CCC32CCN(C[C@@]4(C)CN5C(O4)=NC([N+]([O-])=O)=C5)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wan G, et al. Design, Synthesis, and Antitubercular Activity Evaluation of Novel Nitroimidazole Derivatives. Journal of medicinal chemistry. 2026 Jun 25;69(12):14213-14235. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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