1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Valnoctamide

Valnoctamide (Synonyms: Valmethamide)

Cat. No.: HY-121877 Purity: >99.0%
Handling Instructions

Valnoctamide (Valmethamide), a derivative of valproate, suppresses benzodiazepine-refractory status epilepticus. Valnoctamide (Valmethamide) acts directly on GABAA receptors.

For research use only. We do not sell to patients.

Valnoctamide Chemical Structure

Valnoctamide Chemical Structure

CAS No. : 4171-13-5

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Description

Valnoctamide (Valmethamide), a derivative of valproate, suppresses benzodiazepine-refractory status epilepticus. Valnoctamide (Valmethamide) acts directly on GABAA receptors[1].

IC50 & Target

GABAA receptor[1]

Molecular Weight

143.23

Formula

C₈H₁₇NO

CAS No.

4171-13-5

SMILES

CCC(C(C(N)=O)CC)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (698.18 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.9818 mL 34.9089 mL 69.8178 mL
5 mM 1.3964 mL 6.9818 mL 13.9636 mL
10 mM 0.6982 mL 3.4909 mL 6.9818 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (17.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (17.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (17.45 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

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Product Name:
Valnoctamide
Cat. No.:
HY-121877
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