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Cat. No.: HY-W721258

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Vaniliprole

Name: Vaniliprole
Brand: MedChemExpress
SKU: HY-W721258
Availability: PreOrder

(Synonyms: MMV1794214)

Vaniliprole (MMV1794214) is a phenylpyrazole compound with anti-Toxoplasma gondii activity, with an EC₅₀ of 0.07 μM. Vaniliprole can be used in research related to parasitic infections.

For research use only. We do not sell to patients.

CAS No.: 145767-97-1
Formula: C₂₀H₁₀Cl₂F₆N₄O₂S
Molecular Weight:555.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Vaniliprole Chemical Structure

CAS No.: 145767-97-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Vaniliprole (MMV1794214) is a phenylpyrazole compound with anti-Toxoplasma gondii activity, with an EC₅₀ of 0.07 μM. Vaniliprole can be used in research related to parasitic infections^[1]^[2].

IC₅₀ & Target

^[1]

Toxoplasma

0.07 μM (EC₅₀)

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	EC50	0.07 μM	Inhibition of intracellular Toxoplasma gondii RH-2F1 tachyzoite proliferation in human foreskin fibroblasts assessed by quantifying beta-galactosidase activity after 72 hrs incubation. Inhibition of intracellular Toxoplasma gondii RH-2F1 tachyzoite proliferation in human foreskin fibroblasts assessed by quantifying beta-galactosidase activity after 72 hrs incubation.	42660935
HFF	CC₅₀	>50 μM	Cytotoxicity against uninfected human foreskin fibroblasts assessed by resazurin reduction assay after 72 hrs incubation. Cytotoxicity against uninfected human foreskin fibroblasts assessed by resazurin reduction assay after 72 hrs incubation.	42660935

In Vitro

Parasitic InfectionOthers

Parasitic Infection

Vaniliprole (MMV1794214) (1 μM; 72 h) exhibits anti-Toxoplasma gondii activity against intracellular RH-2F1 tachyzoites in HFF cells, inhibiting parasite growth by ≥80% at 1 μM^[1].
Vaniliprole exhibits potent anti-T. gondii activity against intracellular RH-2F1 tachyzoites in HFF cells with an EC₅₀ of 0.07 μM, and shows low cytotoxicity in uninfected HFFs with a CC₅₀ of greater than 50 μM, resulting in a selectivity index of >756^[1].

Others

Vaniliprole (compound C) derivatives exhibit larvicidal activity against Culex pipiens pallens^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 145767-97-1
Molecular Weight 555.28
Formula C₂₀H₁₀Cl₂F₆N₄O₂S
SMILES

N#CC1=NN(C2=C(C=C(C(F)(F)F)C=C2Cl)Cl)C(/N=C/C3=CC=C(C(OC)=C3)O)=C1SC(F)(F)F
Synonyms

MMV1794214
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sun J, et al. Bis (trifluoromethylthio) carbene as a toolbox for versatile carbene transformations. Nature Communications. 2026 Jul 29.

[2]. Zhao Q, et al. Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety. Journal of agricultural and food chemistry. 2010 Apr 28;58(8):4992-8.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Vaniliprole

All Parasite Isoforms