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Cat. No.: HY-186305

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VL-422 derivative

VL-422 derivative is an ionizable lipid component of targeted lipid nanoparticles. VL-422 derivative formulated with a helper lipid, cholesterol, and a PEGylated lipid forms lipid nanoparticles (LNPs). VL-422 derivative can be used for in vivo or ex vivo delivery of agents to immune cells.

For research use only. We do not sell to patients.

CAS No.: 3078747-38-0
Formula: C₅₃H₁₀₁NO₁₀
Molecular Weight:912.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VL-422 derivative Chemical Structure

CAS No.: 3078747-38-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

VL-422 derivative (47 mol%) formulated in LNPs with DSPC, cholesterol, and PEG-DMG achieves close to 100% transfection efficiency in activated human T cells at doses of 100-800 ng LNP per 2×10⁵ cells
^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VL-422 derivative (systemic) generates functional CAR-T cells in humanized mice, reduces tumor growth, and depletes B cells, demonstrating in vivo efficacy against cancer^[1].
VL-422 derivative (systemic) generates CAR-T cells, depletes B cells, and preserves less differentiated T cell subpopulations long-term in humanized mice engrafted with human CD34⁺ HSCs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3078747-38-0
Molecular Weight 912.37
Formula C₅₃H₁₀₁NO₁₀
SMILES

O=C(CCCN(CC)CC)OCC(COC(CCC(OCCCCCCCC)OCCCCCCCC)=O)COC(CCCCCCC(OC(CCCCCC)CCCCCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gupta M, et al. In vivo delivery of therapeutic agents to T cells. WO2026122998. 11 June 2026.

[2]. Gupta M, et al. In vivo delivery of therapeutic agents to T cells. WO2026122998. 11 June 2026.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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