VU6066761
VU6066761 is a mutant-selective LRRK2 G2019S inhibitor with an IC50 of 0.6 nM. VU6066761 inhibits LRRK2 and Rab10 phosphorylation. VU6066761 can be used for research on Parkinson's disease.
For research use only. We do not sell to patients.
- Formula: C24H31N5O2S
- Molecular Weight:453.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
LRRK2 G2019S 0.6 nM (IC50) |
Rab2 |
In Vitro
VU6066761 inhibits pS935 in G2019S mutant LRRK2 cells with an IC50 of 0.5 nM[1].
VU6066761 preferentially inhibits pS935 LRRK2 and pT73 Rab10 phosphorylation in G2019S mutant LRRK2 cells compared with WT LRRK2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 453.60
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Formula C24H31N5O2S
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SMILES
O=S(C[C@H]1N(C2)C[C@@]([C@@]2([H])C3)([H])C[C@@H]3C4=CC5=C(NN=C5C6=CN(C)N=C6)C=C4C)(CCC1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VU6066761 Related Classifications
HY-190836 Related Classifications
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