Art. -Nr.: HY-13951

Zenidolol hydrochloride

Name: Zenidolol hydrochloride
Brand: MedChemExpress
SKU: HY-13951
Price: 61.00 USD
Availability: InStock
Rating: 5 (50 reviews)

(Synonyms: ICI-118551 hydrochloride)

50 Cited Publications

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Based on 50 publication(s) in Google Scholar

Zenidolol (ICI-118551) hydrochloride is a highly selective β2 adrenergic receptor antagonist, with K_is of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.

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Reinheit : 99.74%
CAS. Nr.: 72795-01-8
Formel: C₁₇H₂₈ClNO₂
Molecular Weight:313.86

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

Zenidolol hydrochloride Chemical Structure

CAS. Nr.: 72795-01-8

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (50)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Zenidolol (ICI-118551) hydrochloride is a highly selective β2 adrenergic receptor antagonist, with K_is of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.

IC₅₀ & Target

β adrenergic receptor

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Zenidolol (ICI-118551) hydrochloride inhibits cAMP accumulation with IC₅₀ of 1.7 μM in IMCD cells^[1].
Zenidolol (ICI-118551; 10 μM) hydrochloride induces a prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO^[2].
In failing human heart, Zenidolol (ICI-118551) hydrochloride has significant effects on beat duration, with time-to-peak contraction and time-to-90% relaxation reduced compared with basal contraction. Negative Inotropic Effect of Zenidolol (ICI-118551) hydrochloride Is Not cAMP-Related. Overexpression of β2AR in rabbit myocytes enhances negative inotropic effects of Zenidolol (ICI-118551) hydrochloride^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Zenidolol (ICI-118551; 0.2 mg/kg) hydrochloride injected into the jugular vein of the mice, reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 72795-01-8
Appearance Solid
Molecular Weight 313.86
Formel C₁₇H₂₈ClNO₂
Color White to light yellow
SMILES

CC1=C(CCC2)C2=C(OC[C@H](O)[C@@H](C)NC(C)C)C=C1.[H]Cl
Synonyms

ICI-118551 hydrochloride
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

Publications (50)

All Cell Proliferation/Viability AssayIFWBCell Imaging/Staining

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Journal Impact Factor

Cancer Cell

Macrophage-mediated brain-bone marrow crosstalk promotes chronic stress-induced glioma growth. [Abstract]

2026 Jun 18:S1535-6108(26)00263-1. PMID: 42314665
Immunity

Hyperactivation of sympathetic nerves fuels basophil infiltration in atopic dermatitis. [Abstract]

2026 Mar 10;59(3):598-617.e11. PMID: 41722568
Cancer Discov

Neuro-mesenchymal interaction mediated by a β2 adrenergic-nerve growth factor feedforward loop promotes colorectal cancer progression. [Abstract]

2025 Jan 13;15(1):202-226. PMID: 39137067
Cancer Res

Netrin-1 Promotes Pancreatic Tumorigenesis and Innervation through NEO1. [Abstract]

2025 Dec 31. PMID: 41474982
Nat Commun

A brain-to-liver signal mediates the inhibition of liver regeneration under chronic stress in mice. [Abstract]

2024 Nov 28;15(1):10361. PMID: 39609433
Nat Commun

Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice. [Abstract]

2023 May 2;14(1):2523. PMID: 37130842
Nat Commun

Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice. [Abstract]

2021 Nov 26;12(1):6937. PMID: 34836959
Nat Commun

DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe. [Abstract]

2020 Sep 25;11(1):4857. PMID: 32978402
Redox Biol

2026 Sep:95:104283. PMID: 42378955
J Exp Clin Cancer Res

Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling. [Abstract]

2019 Apr 25;38(1):174. PMID: 31023336
Adv Sci (Weinh)

Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress-Related Male Reproductive Dysfunction. [Abstract]

2025 Oct 6:e04817. PMID: 41051274

Zenidolol hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]

Zenidolol (ICI118551; ICI) (1 µM; 24-72 H) reversed the NE‐induced reduction in Sertoli cell viability.

Zenidolol hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]

Zenidolol (ICI118551; ICI) (1 µM) reversed NE-induced ACSL4 increase and GPX4 decrease in Sertoli cells.

Zenidolol hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]

Zenidolol (ICI118551; ICI) (1 µM) reversed NE-induced alterations in the expression of SLC7A11, GPX4, and ACSL4 in TM4 cells.

Zenidolol hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]

Zenidolol (ICI118551; ICI) (1 µM) alleviated the NE-induced increase in death of TM4 cells.

Zenidolol hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]

Zenidolol (ICI118551; ICI) (1 µM) normalized tight junction markers ZO-1 and Claudin-11 protein levels in TM4 cells suppressed by NE.
Adv Sci (Weinh)

Sleep Deprivation Triggers the Excessive Activation of Ovarian Primordial Follicles via β2 Adrenergic Receptor Signaling. [Abstract]

2024 Nov;11(41):e2402393. PMID: 39229959
Sci Adv

Sympathetic nerve aggravates autoimmune skin disease via NE-adrenergic receptor axis: Neuroimmune cross-talk insights from vitiligo. [Abstract]

2026 Mar 6;12(10):eaea7017. PMID: 41779853
Sci Adv

Beta2 adrenergic receptor-mediated abnormal myelopoiesis drives neuroinflammation in aged patients with traumatic brain injury. [Abstract]

2024 Jul 19;10(29):eadp5239. PMID: 39028822
Int J Biol Sci

Chronic stress promotes colorectal cancer progression by enhancing glycolysis through β2-AR/CREB1 signal pathway. [Abstract]

2023 Apr 2;19(7):2006-2019. PMID: 37151872

Zenidolol hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2023 Apr 2;19(7):2006-2019. [Abstract]

Zenidolol (ICI; 10 μM; 2 h) abolishes the Epinephrine-induced phosphorylation of CREB1 in MC38 and HT-29 cells.
J Exp Med

IL-6 translation is a therapeutic target of human cytokine release syndrome. [Abstract]

2023 Nov 6;220(11):e20230577. PMID: 37584653
J Pharm Anal

Baicalin reduces chronic stress-induced breast cancer metastasis via directly targeting β2-adrenergic receptor. [Abstract]

2024 Jul;14(7):100934. PMID: 39139999
Diabetes

Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination. [Abstract]

2022 May 1;71(5):921-933. PMID: 35192681
Chin Med J (Engl)

Skin-localized sympathetic nerve-keratinocyte crosstalk fuels psoriatic inflammation via neutrophil recruitment. [Abstract]

2026 Apr 23. PMID: 42036893
Int J Nanomedicine

Bupivacaine Nanoparticles Inhibit Triple-Negative Breast Tumor Growth by Suppressing the Noradrenergic Nerves in Tumor Microenvironment. [Abstract]

2025 May 12:20:6023-6041. PMID: 40385493
Free Radic Biol Med

2026 Oct:254:714-729. PMID: 42419652
Cell Rep

β2AR as a target in methamphetamine addiction: Divergent mechanisms from TAAR1. [Abstract]

2025 Sep 23;44(10):116337. PMID: 40991929
Br J Pharmacol

Pharmacological targeting of β2 -adrenoceptors is neuroprotective in the LPS inflammatory rat model of Parkinson's disease. [Abstract]

2020 Jan;177(2):282-297. PMID: 31506926
Chin Med

2026 Jul 13;21(1):186. PMID: 42443928
Anal Chem

An Allosteric Assay for Identifying Ligands Binding to β2 Adrenergic Receptor by Surface-Enhanced Raman Scattering (SERS)-Active Nanoparticles. [Abstract]

2026 Feb 17;98(6):4895-4904. PMID: 41637639
Commun Biol

Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice. [Abstract]

2022 Apr 8;5(1):339. PMID: 35396348
Commun Biol

Reserpine improves Enterobacteriaceae resistance in chicken intestine via neuro-immunometabolic signaling and MEK1/2 activation. [Abstract]

2021 Dec 3;4(1):1359. PMID: 34862463
J Endocrinol

β2AR against myocarditis-lipid deposition depends on estrogenic environment in stress. [Abstract]

2023 Feb 16;256(3):e220335. PMID: 36633355
Eur J Pharmacol

Dopamine regulates astrocytic IL-6 expression and process formation via dopamine receptors and adrenoceptors. [Abstract]

2022 Aug 5:928:175110. PMID: 35738452
Invest Ophthalmol Vis Sci

Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice. [Abstract]

2025 Jun 2;66(6):13. PMID: 40465266
Int Dent J

Blocking β2-AR and Inhibiting COX-2: A Promising Approach to Suppress OSCC Development. [Abstract]

2025 Apr;75(2):807-816. PMID: 39043526
J Nutr Biochem

Genistein rescues hypoxia-induced pulmonary arterial hypertension through estrogen receptor and β-adrenoceptor signaling. [Abstract]

2018 Aug:58:110-118. PMID: 29886191

Zenidolol hydrochloride purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2018 Aug:58:110-118. [Abstract]

PASMCs are pretreated with or not Norepinephrine (50 μM) or ICI 118,551 (5 nM), and α-SMA (D) are analyzed.
Oncol Rep

Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib. [Abstract]

2016 Sep;36(3):1576-84. PMID: 27432558

Zenidolol hydrochloride purchased from MedChemExpress. Usage Cited in: Oncol Rep. 2016 Sep;36(3):1576-84. [Abstract]

Western blotting of Bcl-2 expression in 8505C lysates after in vitro pharmacologic interventions using propranolol and ICI118551 for 24 h. Western blotting of AKT, p-AKT, mTOR, p-mTOR in 8505C lysates after in vitro pharmacologic interventions using propranolol and ICI118551for 24 h.
Mol Oncol

NNK from tobacco smoking enhances pancreatic cancer cell stemness and chemoresistance by creating a β2AR-Akt feedback loop that activates autophagy. [Abstract]

2022 Aug;16(15):2881-2895. PMID: 35593085
BMC Cancer

β2AR-HIF-1α-CXCL12 signaling of osteoblasts activated by isoproterenol promotes migration and invasion of prostate cancer cells. [Abstract]

2019 Nov 26;19(1):1142. PMID: 31771535
Neuroscience

Natural Killer Cells may Exert Antidepressant-like Effects in Mice by Controlling the Release of Inflammatory Factors. [Abstract]

2019 Mar 1:401:59-72. PMID: 30641114
Pflugers Arch

Increased β-adrenergic stimulation augments vascular smooth muscle cell calcification via PKA/CREB signalling. [Abstract]

2021 Dec;473(12):1899-1910. PMID: 34564739
Biochem Biophys Res Commun

Olodaterol promotes thermogenesis in brown adipocytes via regulation of the β2-AR/cAMP/PKA signaling pathway. [Abstract]

2024 Apr 9:703:149689. PMID: 38382361
J Oral Maxillofac Surg

Overexpression of β-Adrenergic Receptors and the Suppressive Effect of β2-Adrenergic Receptor Blockade in Oral Squamous Cell Carcinoma. [Abstract]

2020 Oct;78(10):1871.e1-1871.e23. PMID: 32640209
BMC Ophthalmol

β-blocker eye drops affect ocular surface through β2 adrenoceptor of corneal limbal stem cells. [Abstract]

2021 Dec 5;21(1):419. PMID: 34863129
bioRxiv

Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1. [Abstract]

2025 Jul 26:2025.07.22.666009. PMID: 40777309
Environ Toxicol

Phenylacetyl glutamine (PAGln) enhances cardiomyocyte death after myocardial infarction through β1 adrenergic receptor. [Abstract]

2024 Mar;39(3):1682-1699. PMID: 38041472
bioRxiv

2024 Feb 19.
Biomed Pharmacother

Interference of sympathetic overactivation restores limbal stem/progenitor cells function and accelerates corneal epithelial wound healing in diabetic mice. [Abstract]

2023 May:161:114523. PMID: 36931034
Research Square Preprint

2022 Mar.
Research Square Preprint

2021 Nov.
Research Square Preprint

2021 Sep.
Research Square Preprint

2021 Feb.
Research Square Preprint

2020 Oct.
bioRxiv

2020 Jan.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (79.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 8.33 mg/mL (26.54 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1861 mL

15.9307 mL

31.8613 mL

5 mM

0.6372 mL

3.1861 mL

6.3723 mL

10 mM

0.3186 mL

1.5931 mL

3.1861 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 1 mg/mL (3.19 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yasuda G, et al. The beta 1- and beta 2-adrenoceptor subtypes in cultured rat inner medullary collecting duct cells. Am J Physiol. 1996 Sep;271(3 Pt 2):F762-9. [Content Brief]

[2]. Wenzel D, et al. beta(2)-adrenoceptor antagonist ICI 118,551 decreases pulmonary vascular tone in mice via a G(i/o) protein/nitric oxide-coupled pathway. Hypertension. 2009 Jul;54(1):157-63. [Content Brief]

[3]. Gong H, et al. Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart. Circulation. 2002 May 28;105(21):2497-503. [Content Brief]

[4]. Hoffmann C, et al. Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):151-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	3.1861 mL	15.9307 mL	31.8613 mL	79.6534 mL
	5 mM	0.6372 mL	3.1861 mL	6.3723 mL	15.9307 mL
	10 mM	0.3186 mL	1.5931 mL	3.1861 mL	7.9653 mL
	15 mM	0.2124 mL	1.0620 mL	2.1241 mL	5.3102 mL
	20 mM	0.1593 mL	0.7965 mL	1.5931 mL	3.9827 mL
	25 mM	0.1274 mL	0.6372 mL	1.2745 mL	3.1861 mL
DMSO	30 mM	0.1062 mL	0.5310 mL	1.0620 mL	2.6551 mL
	40 mM	0.0797 mL	0.3983 mL	0.7965 mL	1.9913 mL
	50 mM	0.0637 mL	0.3186 mL	0.6372 mL	1.5931 mL
	60 mM	0.0531 mL	0.2655 mL	0.5310 mL	1.3276 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bioz

Keywords

Zenidolol hydrochloride

50 Cited Publications

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Zenidolol hydrochloride

Publications Citing Use of MedChemExpress (MCE) Zenidolol hydrochloride

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen