γ-Fagarine
Based on 1 Customer Validation
γ-Fagarine is a furoquinoline alkaloid naturally occurring in Rutae Herba. γ-Fagarine has strong anti-HCV activities with IC50 of 20.4 μg/mL and is also a sister chromatid exchanges (SCEs) inducer.
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- Reinheit : 99.73%
- CAS. Nr.: 524-15-2
- Formel: C13H11NO3
- Molecular Weight:229.23
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-12530R
Velpatasvir (Standard)HCV NS5A Inhibitor -
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TrachelogeninHCV Entry Inhibitor
Biologische Aktivität
Beschreibung
IC50 & Target
IC50: 20.4 μg/mL (HCV)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
>160 μM
Compound: 16
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Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay
Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay
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[PMID: 22093759] |
| Neutrophil | IC50 |
>100 μM
Compound: 8
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Antiinflammatory activity in human neutrophils assessed as fMLP-induced superoxide release after 5 mins by spectrometry
Antiinflammatory activity in human neutrophils assessed as fMLP-induced superoxide release after 5 mins by spectrometry
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[PMID: 17822293] |
| Neutrophil | IC50 |
>50 μM
Compound: 16
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Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced elastase release
Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced elastase release
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[PMID: 18211005] |
| Neutrophil | IC50 |
31.31 μM
Compound: 16
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Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced superoxide anion generation
Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced superoxide anion generation
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[PMID: 18211005] |
| Neutrophil | IC50 |
7.17 μg/mL
Compound: Gamma-fagarine
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Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation
Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation
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[PMID: 19128011] |
Chemical Information
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CAS. Nr. 524-15-2
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Appearance Solid
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Molecular Weight 229.23
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Formel C13H11NO3
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Color White to off-white
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SMILES
COC1=C2N=C(OC=C3)C3=C(OC)C2=CC=C1
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Tutik Sri Wahyuni, et al. Inhibition of Hepatitis C Virus Replication by Chalepin and Pseudane IX Isolated From Ruta Angustifolia Leaves. Fitoterapia. 2014 Dec;99:276-83. [Content Brief]
[2]. O Schimmer, et al. The SCE-inducing Potency of the Furoquinoline Alkaloid, Gamma-Fagarine, and a Gamma-Fagarine-Containing Tincture From Rutae Herba, in Cultured Human Lymphocytes. Mutagenesis. 1989 Nov;4(6):467-70. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
γ-Fagarine Related Classifications
HY-N3918 Related Classifications
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