2. Anti-infection
  3. HCV
  4. γ-Fagarine

γ-Fagarine is a furoquinoline alkaloid naturally occurring in Rutae Herba. γ-Fagarine has strong anti-HCV activities with IC50 of 20.4 μg/mL and is also a sister chromatid exchanges (SCEs) inducer.

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γ-Fagarine

γ-Fagarine Chemical Structure

CAS No. : 524-15-2

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Based on 1 publication(s) in Google Scholar

γ-Fagarine Related Antibodies

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Description

γ-Fagarine is a furoquinoline alkaloid naturally occurring in Rutae Herba. γ-Fagarine has strong anti-HCV activities with IC50 of 20.4 μg/mL and is also a sister chromatid exchanges (SCEs) inducer[1][2].

IC50 & Target

IC50: 20.4 μg/mL (HCV)[1]
Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
> 160 μM
Compound: 16
Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay
Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay
[PMID: 22093759]
Neutrophil IC50
31.31 μM
Compound: 16
Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced superoxide anion generation
Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced superoxide anion generation
[PMID: 18211005]
Neutrophil IC50
7.17 μg/mL
Compound: Gamma-fagarine
Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation
Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation
[PMID: 19128011]
Neutrophil IC50
> 100 μM
Compound: 8
Antiinflammatory activity in human neutrophils assessed as fMLP-induced superoxide release after 5 mins by spectrometry
Antiinflammatory activity in human neutrophils assessed as fMLP-induced superoxide release after 5 mins by spectrometry
[PMID: 17822293]
Neutrophil IC50
> 50 μM
Compound: 16
Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced elastase release
Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced elastase release
[PMID: 18211005]
Molecular Weight

229.23

Formula

C13H11NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=C2N=C(OC=C3)C3=C(OC)C2=CC=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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γ-Fagarine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

γ-Fagarine524-15-2HCVHepatitis C virusSCEsfuroquinolinealkaloidanti-HCVInhibitorinhibitorinhibit

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