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Cat. No.: HY-176405

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σ1R-IN-1

σ1R-IN-1 ((R,R)-1a) is a potent σ-1R inhibitor with an IC₅₀ of 110 nM. σ1R-IN-1 is promising for research of neuropsychiatric disorders.

For research use only. We do not sell to patients.

Formula: C₁₅H₂₂N₂
Molecular Weight:230.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

σ1R-IN-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

σ1R-IN-1 ((R,R)-1a) is a potent σ-1R inhibitor with an IC₅₀ of 110 nM. σ1R-IN-1 is promising for research of neuropsychiatric disorders^[1].

All Sigma Receptor Isoforms :

Chemical Information

Molecular Weight 230.35
Formula C₁₅H₂₂N₂
SMILES

[C@@H]1(CCN2)[C@H]2CCCCN1CC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Carrel A, et al. Exploring Simple Drug Scaffolds from the Generated Database Chemical Space Reveals a Chiral Bicyclic Azepane with Potent Neuropharmacology. J Med Chem. 2025 May 8;68(9):9176-9201. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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