1. Epigenetics
  2. Histone Demethylase
  3. α-Hydroxyglutaric acid

α-Hydroxyglutaric acid (Synonyms: 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid)

Cat. No.: HY-113038B
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α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.

For research use only. We do not sell to patients.

α-Hydroxyglutaric acid Chemical Structure

α-Hydroxyglutaric acid Chemical Structure

CAS No. : 2889-31-8

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Description

α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].

In Vitro

Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate), respectively[1].
α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of TET 5-methylcytosine hydroxylases[1].
Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) increases HIF-1α and decreases endostatin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

148.11

Formula

C₅H₈O₅

CAS No.

2889-31-8

SMILES

O=C(O)C(O)CCC(O)=O

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Keywords:

α-Hydroxyglutaric acid2-Hydroxyglutarate 2-Hydroxyglutaric acid 2-Hydroxypentanedioic acidHistone DemethylaseCell-permeable5-methylcytosineα-ketoglutaratedioxygenasesIDH1IDH2Inhibitorinhibitorinhibit

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α-Hydroxyglutaric acid
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