1-Methylpyrrolidine
Based on 1 Customer Validation
1-Methylpyrrolidine is a methylated pyrrolidine, and cation with thermal-origin negative nonlinear optical (self-defocusing) properties.
For research use only. We do not sell to patients.
- Purity: 99.02%
- CAS No.: 120-94-5
- Formula: C5H11N
- Molecular Weight:85.15
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
1-Methylpyrrolidine forms part of a family of ionic liquids. 1-Methylpyrrolidine acts as a ligand for MoOCl4 in CH3CN solvent to form the complex MoO2Cl2·(C4H8NCH3)2Cl2[1].
1-Methylpyrrolidine serves as a precursor for polyfluorinated 1-methylpyrrolidine derivatives via fluorination with cobalt(III) fluoride[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 120-94-5
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Appearance Liquid (Density: 0.819 g/cm3 )
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Molecular Weight 85.15
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Formula C5H11N
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Color Colorless to light yellow
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SMILES
CN1CCCC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (1174.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (29.36 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (29.36 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (936 KB)
- English - EN (936 KB)
- Français - FR (936 KB)
- Deutsch - DE (936 KB)
- Norwegian - NO (936 KB)
- Español - ES (936 KB)
- Swedish - SV (936 KB)
- Italian - IT (936 KB)
- Korean - KR (936 KB)
- Portuguese - PT (936 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 11.7440 mL | 58.7199 mL | 117.4398 mL | 293.5995 mL |
| 5 mM | 2.3488 mL | 11.7440 mL | 23.4880 mL | 58.7199 mL | |
| 10 mM | 1.1744 mL | 5.8720 mL | 11.7440 mL | 29.3600 mL | |
| 15 mM | 0.7829 mL | 3.9147 mL | 7.8293 mL | 19.5733 mL | |
| 20 mM | 0.5872 mL | 2.9360 mL | 5.8720 mL | 14.6800 mL | |
| 25 mM | 0.4698 mL | 2.3488 mL | 4.6976 mL | 11.7440 mL | |
| 30 mM | 0.3915 mL | 1.9573 mL | 3.9147 mL | 9.7867 mL | |
| 40 mM | 0.2936 mL | 1.4680 mL | 2.9360 mL | 7.3400 mL | |
| 50 mM | 0.2349 mL | 1.1744 mL | 2.3488 mL | 5.8720 mL | |
| 60 mM | 0.1957 mL | 0.9787 mL | 1.9573 mL | 4.8933 mL | |
| 80 mM | 0.1468 mL | 0.7340 mL | 1.4680 mL | 3.6700 mL | |
| 100 mM | 0.1174 mL | 0.5872 mL | 1.1744 mL | 2.9360 mL |
1-Methylpyrrolidine Related Classifications
Cat. No.: HY-128383
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- 1-Methylpyrrolidine
- 120-94-5
- Environmental Pollutants
- Drug Intermediate
- cyclic tertiary amine
- CH3CN
- negative nonlinear optical properties
- self-defocusing
- cobalt(III) fluoride
- N-heterocyclic ligand
- MoO2Cl2·(C4H8NCH3)2Cl2
- polyfluorinated 1-methylpyrrolidine derivatives
- ionic liquids
- MoOCl4
- Inhibitor
- inhibitor
- inhibit