15-Deoxy-Δ-12,14-prostaglandin J2
Based on 3 publication(s) in Google Scholar
15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM.
For research use only. We do not sell to patients.
- Purity : 97.0%
- CAS No.: 87893-55-8
- Formula: C20H28O3
- Molecular Weight:316.43
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) 15-Deoxy-Δ-12,14-prostaglandin J2
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
PPARγ 2 μM (EC50) |
PPARδ |
Human Endogenous Metabolite |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
2.2 μM
Compound: 15d-PGJ2
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Suppression of LPS/IFN-gamma-stimulated NO production in mouse RAW264.7 cells
Suppression of LPS/IFN-gamma-stimulated NO production in mouse RAW264.7 cells
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[PMID: 18809325] |
In Vitro
15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a cyclopentenone prostaglandin that features an electrophilic, α, β-unsaturated ketone (an enone) in the cyclopentenone ring. 15-Deoxy-Δ-12,14-prostaglandin J2 is one of the cyPGs whose functions in inflammation, cell proliferation, survival, and apoptosis have been documented. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ in a dose-dependent manner. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ’s transcriptional activity through formation of a covalent adduct between its endocyclic enone at C9 and Cys249 in the receptor’s ligand-binding domain[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 87893-55-8
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Appearance Liquid
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Molecular Weight 316.43
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Formula C20H28O3
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Color Colorless to light yellow
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SMILES
CCCCC/C=C/C=C1[C@H](C=CC\1=O)C/C=C\CCCC(O)=O
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Synonyms
15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Publications (3)
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Journal Impact Factor
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Most Recent
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Ecotoxicol Environ Saf
Polystyrene microplastics induces senescence of osteocytes by activating the cyclooxygenase-2 signaling pathway. [Abstract]2025 Jul 15:300:118466. PMID: 40466333 -
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Purity & Documentation
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Data Sheet (276 KB)
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SDS (605 KB)
- English - EN (605 KB)
- Français - FR (605 KB)
- Deutsch - DE (605 KB)
- Norwegian - NO (605 KB)
- Español - ES (605 KB)
- Swedish - SV (605 KB)
- Italian - IT (605 KB)
- Korean - KR (605 KB)
- Portuguese - PT (605 KB)
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Handling Instructions (2659 KB)
References
[1]. Reddy AT, et al. Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor δ as a Novel Target for Covalent Modification by 15-Deoxy-Δ12,14-prostaglandin J2. CS Chem Biol. 2018 Dec 21;13(12):3269-3278. [Content Brief]
[2]. Kliewer SA1, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83(5):813-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
15-Deoxy-Δ-12,14-prostaglandin J2 Related Classifications
HY-108568 Related Classifications
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