2-Fluoroneplanocin A

2-Fluoroneplanocin A inhibits rabbit erythrocyte AdoHcy hydrolase with an IC₅₀ of 0.20 μg/mL^[1].
2-Fluoroneplanocin A (0.03-1.2 μg/mL; 37 h) inhibits vesicular stomatitis virus (IC₅₀ = 0.25 μg/mL), measles virus (IC₅₀ = 0.03 μg/mL), and mumps virus (IC₅₀ = 1.2 μg/mL) in Vero cells, with no cytotoxicity at concentrations up to 200 μg/mL^[1].
2-Fluoroneplanocin A exhibits potent antiviral activity against vaccinia virus (IC₅₀ = 0.1 μg/mL), vesicular stomatitis virus (IC₅₀ = 0.4-1 μg/mL), parainfluenza-3 (IC₅₀ = 2 μg/mL), Reo-1 (IC₅₀ = 0.7 μg/mL), Junin (IC₅₀ = 0.6 μg/mL), and Tacaribe (IC₅₀ = 0.7 μg/mL) across E6SM, HeLa, Vero, and HEL cell lines, with weaker or no activity against other tested viruses^[1].
2-Fluoroneplanocin A inhibits the growth of HEL cells (IC₅₀ = 2 μg/mL), L1210 cells (IC₅₀ = 0.25 μg/mL), FM3A cells (IC₅₀ = 0.19 μg/mL), MOLT-4 cells (IC₅₀ = 0.50 μg/mL), and CEM cells (IC₅₀ = 1.75 μg/mL), with weaker activity against E6SM, HeLa, and Vero cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.