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Cat. No.: HY-N21795

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2-Hydroxydendrobine

2-Hydroxydendrobine is a dendrobine-type alkaloid. 2-Hydroxydendrobine is isolated from the stems of Dendrobium findlayanum. 2-Hydroxydendrobine exhibits no inhibitory activity against lipopolysaccharide-stimulated nitric oxide production. 2-Hydroxydendrobine is used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 29414-86-6
Formula: C₁₆H₂₅NO₃
Molecular Weight:279.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

2-Hydroxydendrobine Chemical Structure

CAS No.: 29414-86-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC50	>40 μM	Cytotoxicity against human HL-60 promyelocytic leukemia cells, with IC50 greater than 40 μM indicating inactivity. Cytotoxicity against human HL-60 promyelocytic leukemia cells, with IC50 greater than 40 μM indicating inactivity.	29338260
SMMC-7721	IC50	>40 μM	Cytotoxicity against human SMMC-7721 hepatocellular carcinoma cells, with IC50 greater than 40 μM indicating inactivity. Cytotoxicity against human SMMC-7721 hepatocellular carcinoma cells, with IC50 greater than 40 μM indicating inactivity.	29338260
A549	IC50	>40 μM	Cytotoxicity against human A-549 lung adenocarcinoma cells, with IC50 greater than 40 μM indicating inactivity. Cytotoxicity against human A-549 lung adenocarcinoma cells, with IC50 greater than 40 μM indicating inactivity.	29338260
MCF7	IC50	>40 μM	Cytotoxicity against human MCF-7 breast adenocarcinoma cells, with IC50 greater than 40 μM indicating inactivity. Cytotoxicity against human MCF-7 breast adenocarcinoma cells, with IC50 greater than 40 μM indicating inactivity.	29338260
SW480	IC50	>40 μM	Cytotoxicity against human SW480 colon adenocarcinoma cells, with IC50 greater than 40 μM indicating inactivity. Cytotoxicity against human SW480 colon adenocarcinoma cells, with IC50 greater than 40 μM indicating inactivity.	29338260

In Vitro

2-hydroxydendrobine exhibits no measurable cytotoxic activity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human cancer cell lines, with IC₅₀ values above 40 μM in all cases^[1].
2-hydroxydendrobine (25 μM) does not inhibit nitric oxide production in LPS-stimulated RAW 264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 29414-86-6
Molecular Weight 279.38
Formula C₁₆H₂₅NO₃
SMILES

C[C@@]12[C@@]3(O)[C@]4([C@@H]([C@@H](C)C)[C@@]([C@@]1(CC[C@@]2(CN3C)[H])[H])(C(=O)O4)[H])[H]
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang D, et al. Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum. Journal of natural products. 2018 Feb 23;81(2):227-235. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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