3-Hydroxyhippuric acid-d4
3-Hydroxyhippuric acid-d4 is the deuterium labeled 3-Hydroxyhippuric acid (HY-113085). 3-Hydroxyhippuric acid is an acyl glycine. 3-Hydroxyhippuric acid inhibits kynureninase (Ki = 60 μM). 3-Hydroxyhippuric acid is found in higher concentrations in autistic group than in the controls. 3-Hydroxyhippuric acid is a marker of Clostridium species, and has a positive correlation with the level of Clostridia. 3-Hydroxyhippuric acid is one of the main metabolites formed from the catechin diet and wine polyphenol diets.
For research use only. We do not sell to patients.
- Formula: C9H5D4NO4
- Molecular Weight:199.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 1637-75-8
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Molecular Weight 199.20
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Formula C9H5D4NO4
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SMILES
O=C(O)CNC(C1=C([2H])C([2H])=C([2H])C(O)=C1[2H])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Xiong, X., et al., (2016). Urinary 3-(3-Hydroxyphenyl)-3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders. BioMed research international, 2016, 9485412. [Content Brief]
[2]. Gonthier, M. P., et al., (2003). Microbial aromatic acid metabolites formed in the gut account for a major fraction of the polyphenols excreted in urine of rats fed red wine polyphenols. The Journal of nutrition, 133(2), 461–467. [Content Brief]
[3]. Lima, S., Kumar, S., (2009). Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity. Journal of medicinal chemistry, 52(2), 389–396. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3-Hydroxyhippuric acid-d4 Related Classifications
HY-178381S Related Classifications
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