6'-Sialyllactose
Based on 1 publication(s) in Google Scholar
6'-Sialyllactose promotes the growth of beneficial bacteria (such as Bifidobacterium and lactobacillus) and inhibits the proliferation of harmful bacteria. 6'-Sialyllactose exhibits anti-inflammatory and anti-angiogenic activities. 6'-Sialyllactose promotes the muscle health.
For research use only. We do not sell to patients.
- Purity : 99.60%
- CAS No.: 35890-39-2
- Formula: C23H39NO19
- Molecular Weight:633.55
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-N10528
3-FucosyllactoseFucosylated Oligosaccharide -
HY-N9448
Lacto-N-tetraoseOligosaccharides -
HY-108065A
3'-Sialyllactose sodiumPrebiotic -
HY-137335
6'-Sialyllactose sodiumMilk Oligosaccharide -
HY-W019806
Lacto-N-fucopentaose IHuman Milk Oligosaccharide -
HY-N9965
2'-FucosyllactoseImmunomodulator -
HY-N1362
Salvianolic acid BAntioxidant -
HY-W088070A
Agarose,Low melting pointBiochemical Assay Reagent -
HY-B2123
LactoseMacronutrient -
HY-N2024A
Maltose monohydrateDegradative Product of Starch -
HY-W087904
α-Lactose hydrateBiochemical Assay Reagents -
HY-N7575
Lacto-N-fucopentaose IISialyl Lewis Hapten
Publications Citing Use of MedChemExpress (MCE) 6'-Sialyllactose
MoreAll VEGFR Isoforms
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Biological Activity
Description
In Vitro
6'-Sialyllactose (0-50 μM, 24 h) inhibits Dihydrotestosterone-induced proliferation of HUVECs, suppresses tubular structure formation, inhibits the activation of VEGFR-2-related Akt-ERK signaling pathway[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:HUVEC
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Concentration:0-50 μM
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Incubation Time:24 h
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Result:Downregulated levels of p-Akt and p-ERK.
In Vivo
6'-Sialyllactose (100 mg/kg, po, once daily, 5 times a week for 12 weeks) increases the muscle mass and strength, thereby improving the exercise endurance of mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SDR-stressed mouse model[2]
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Dosage:5% added to mouse diet
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Administration:po, 2 weeks
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Result:Reduced the anxiety-like behavior in open field tests.
Maintained the number of DCX-positive cells in the hippocampus.
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Animal Model:C57BL/6J mouse models[3]
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Dosage:100 mg/kg
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Administration:po, once daily, 5 times a week for 12 weeks
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Result:Increased the mouse running distance.
Increased the absolute weight of gastrocnemius and soleus muscles.
Chemical Information
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CAS No. 35890-39-2
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Appearance Solid
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Molecular Weight 633.55
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Formula C23H39NO19
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Color White to off-white
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SMILES
O=C[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]([C@@H]([C@H]([C@H]1O)O)O)O[C@@H]1CO[C@]2(O[C@@]([C@@H]([C@H](C2)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)C(O)=O
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Structure Classification
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Initial Source
Clostridium perfringens
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Future Sci OA
The potential of human milk oligosaccharides in ameliorating traumatic brain injury-induced cognitive impairment in mice. [Abstract]2026 Dec;12(1):2622241. PMID: 41622772
Solvent & Solubility
In Vitro:
H2O : ≥ 50 mg/mL (78.92 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
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Data Sheet (283 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[2]. Tarr AJ, et al., The prebiotics 3'Sialyllactose and 6'Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut-brain axis. Brain Behav Immun. 2015 Nov;50:166-177. [Content Brief]
[3]. Park EJ, et al., 6'-Sialyllactose Enhances Exercise Performance via Increased Muscle Mass and Strength. Nutrients. 2024 Aug 7;16(16):2600. [Content Brief]
[4]. Kim EY, et al., 6-sialyllactose ameliorates dihydrotestosterone-induced benign prostatic hyperplasia through suppressing VEGF-mediated angiogenesis. BMB Rep. 2019 Sep;52(9):560-565. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.5784 mL | 7.8920 mL | 15.7841 mL | 39.4602 mL |
| 5 mM | 0.3157 mL | 1.5784 mL | 3.1568 mL | 7.8920 mL | |
| 10 mM | 0.1578 mL | 0.7892 mL | 1.5784 mL | 3.9460 mL | |
| 15 mM | 0.1052 mL | 0.5261 mL | 1.0523 mL | 2.6307 mL | |
| 20 mM | 0.0789 mL | 0.3946 mL | 0.7892 mL | 1.9730 mL | |
| 25 mM | 0.0631 mL | 0.3157 mL | 0.6314 mL | 1.5784 mL | |
| 30 mM | 0.0526 mL | 0.2631 mL | 0.5261 mL | 1.3153 mL | |
| 40 mM | 0.0395 mL | 0.1973 mL | 0.3946 mL | 0.9865 mL | |
| 50 mM | 0.0316 mL | 0.1578 mL | 0.3157 mL | 0.7892 mL | |
| 60 mM | 0.0263 mL | 0.1315 mL | 0.2631 mL | 0.6577 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
6'-Sialyllactose Related Classifications
HY-N10521 Related Classifications
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