7α-Hydroxycholesterol (Standard)
7α-Hydroxycholesterol is a cholesterol oxide and can serve as a biomarker for oxidative stress and lipid peroxidation. 7α-Hydroxycholesterol has cytotoxic and pro-inflammatory activities. 7α-Hydroxycholesterol can also inhibit sterol synthesis and reduce the activity of HMG-CoA reductase. 7α-Hydroxycholesterol can be used in the research of diseases such as diabetes and atherosclerosis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 566-26-7
- Fòrmula: C27H46O2
- Peso molecular:402.65
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Pureza y Documentación
-
Help & FAQs
-
HY-N7264
7α-HydroxycholesterolCholesterol Oxide -
HY-113224
DesmosterolEndogenous Metabolite -
HY-154921
Lactosylceramide (bovine buttermilk)Glycosphingolipid -
HY-113224R
Desmosterol (Standard)Endogenous Metabolite -
HY-130502
5β,6β-EpoxycholestanolOxysterol -
HY-139170
CAY10746ROCK Inhibitor -
HY-W010695
Cholesteryl stearateBiochemical Assay Reagent -
HY-W010695R
Cholesteryl stearate (Standard)Biochemical Assay Reagent -
HY-123016A
(±)9-HODE cholesteryl ester -
HY-125394
9(R)-HODE cholesteryl ester -
HY-165875
13(R)-HODE Cholesteryl esterEster Product -
HY-17589S
Chloroquine-d5 diphosphateStable Isotope
Product Information
Information
Aplicación
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
No. CAS 566-26-7
-
Peso molecular 402.65
-
Fòrmula C27H46O2
-
SMILES
CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
-
Structure Classification
-
Initial Source
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Nury T, et al. Improved synthesis and in vitro evaluation of the cytotoxic profile of oxysterols oxidized at C4 (4α- and 4β-hydroxycholesterol) and C7 (7-ketocholesterol, 7α- and 7β-hydroxycholesterol) on cells of the central nervous system. Eur J Med Chem. 2013;70:558-67. [Content Brief]
[2]. Kandutsch AA, et al. Inhibition of sterol synthesis in cultured mouse cells by 7alpha-hydroxycholesterol, 7beta-hydroxycholesterol, and 7-ketocholesterol. J Biol Chem. 1973 Dec 25;248(24):8408-17. [Content Brief]
[3]. Son Y, et al. Glucocorticoids Impair the 7α-Hydroxycholesterol-Enhanced Innate Immune Response. Immune Netw. 2023 Oct 19;23(5):e40. [Content Brief]
[4]. Ferderbar S, et al. Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus. Diabetes Metab Res Rev. 2007 Jan;23(1):35-42. [Content Brief]
[5]. Kitano S, et al. Oxidative status of human low density lipoprotein isolated by anion-exchange high-performance liquid chromatography--assessment by total hydroxyoctadecadienoic acid, 7-hydroxycholesterol, and 8-iso-prostaglandin F(2alpha). Anal Chim Acta. 2007 Feb 28;585(1):86-93. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
7α-Hydroxycholesterol (Standard) Related Classifications
HY-N7264R Related Classifications
Powered by Bioz