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Cat. No.: HY-N16702

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8-Demethyleucalyptin

8-Demethyleucalyptin is a natural flavonoid.

For research use only. We do not sell to patients.

CAS No.: 5689-38-3
Formula: C₁₈H₁₆O₅
Molecular Weight:312.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

8-Demethyleucalyptin Chemical Structure

CAS No.: 5689-38-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

8-Demethyleucalyptin is a natural flavonoid.

In Vitro

8-Demethyleucalyptin (Compound C2) exhibits bacteriostatic activity against MSSA ATCC 25923 and MRSA ATCC 33591 with MIC of 31.25 μg/mL and 62.5 μg/mL^[1].
8-Demethyleucalyptin (15.625-31.25 μg/mL; 48 h) inhibits biofilm formation of MRSA and MSSA with inhibition rate of 31.6% and 37.1%^[1].
8-Demethyleucalyptin (15.625-31.25 μg/mL; 48 h) weakly inhibits staphyloxanthin biosynthesis of MRSA and MSSA with inhibition rate of 14.2% and 22.2% and reduces acid tolerance^[1].
8-Demethyleucalyptin (31.25-62.5 μg/mL; 18 h) disrupts cell membrane and wall integrity in MSSA and MRSA^[1].
8-Demethyleucalyptin (48-72 h) inhibits HCT116 and MRC-5 cells viability (IC₅₀ = 6.4 and 7.0 μM and IC₅₀ >100 μM for Jurkat cells)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 5689-38-3
Molecular Weight 312.32
Formula C₁₈H₁₆O₅
SMILES

O=C1C=C(C2=CC=C(OC)C=C2)OC3=C1C(O)=C(C)C(OC)=C3
Structure Classification
- Flavonoids
- Other Flavonoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shehabeldine AM, et al. Callistemon citrinus bioactive metabolites as new inhibitors of methicillin-resistant Staphylococcus aureus biofilm formation. J Ethnopharmacol. 2020;254:112669. [Content Brief]

[2]. Asakawa R, et al. Synthesis and cytotoxic activities of 8- and 6-demethyleucalyptins. Biosci Biotechnol Biochem. 2022;86(9):1200-1206. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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