8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate

Cat. No.: HY-134664: Data Sheet Handling Instructions
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8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC₅₀s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC₅₀s of 60.2 and 38.6 μM, respectively.

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8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate 화학구조

CAS No. : 67667-71-4

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

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This product is a controlled substance and not for sale in your territory.

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•Related Small Molecules:

•Related Proteins:

View All Monoamine Oxidase Isoform Specific Products:

View All Isoforms

MAO-A MAO-B

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

IC50: 8.64 μM (CYP2A6, pre-incubation), 22.3 μM (CYP2A6, co-incubation), 38.6 μM (MAO-B), 60.2 μM(MAO-A)^[1]
Ki: 15.1 μM (CYP2A6), 27.2 μM (MAO-B), 60.2 μM (MAO-A)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	5.2 μM Compound: 5	Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay	[PMID: 22850207]
MCF7	IC₅₀	7.7 μM Compound: 7	Antiproliferative activity against human MCF7 cells for 72 hrs by cyquant assay Antiproliferative activity against human MCF7 cells for 72 hrs by cyquant assay	[PMID: 26331426]
MDA-MB-231	IC₅₀	5.2 μM Compound: 7	Antiproliferative activity against human MDA-MB-231 cells for 72 hrs by cyquant assay Antiproliferative activity against human MDA-MB-231 cells for 72 hrs by cyquant assay	[PMID: 26331426]
NIH3T3	IC₅₀	7.1 μM Compound: 7	Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by cyquant cells Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by cyquant cells	[PMID: 26331426]
RAW264.7	IC₅₀	6.6 μM Compound: 5	Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method	[PMID: 22850207]
SF-295	IC₅₀	9.1 μM Compound: 7	Antiproliferative activity against human SF295 cells for 72 hrs by cyquant assay Antiproliferative activity against human SF295 cells for 72 hrs by cyquant assay	[PMID: 26331426]
U-251	IC₅₀	2.6 μM Compound: 7	Antiproliferative activity against human U251MG cells for 72 hrs by cyquant assay Antiproliferative activity against human U251MG cells for 72 hrs by cyquant assay	[PMID: 26331426]
U-373MG ATCC	IC₅₀	8.3 μM Compound: 7	Antiproliferative activity against human U373MG cells for 72 hrs by cyquant assay Antiproliferative activity against human U373MG cells for 72 hrs by cyquant assay	[PMID: 26331426]

분자량

406.43

화학식

C₂₁H₂₆O₈

CAS No.

67667-71-4

SMILES

CC(OCC1=C([C@H](C[C@H]2C)OC(C(C)=C)=O)/C(OC1=O)=C\[C@](O[C@]23O)(CC3)C)=O

Structure Classification

Initial Source

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Prasopthum A, et al. Inhibition effects of Vernonia cinerea active compounds against cytochrome P450 2A6 and human monoamine oxidases, possible targets for reduction of tobacco dependence. Drug Metab Pharmacokinet. 2015 Apr;30(2):174-81. [Content Brief]