9-Ethylguanine
Based on 1 Customer Validation
9-Ethylguanine is a modified nucleobase derived from guanine that coordinates to azolato-bridged dinuclear platinum(II) complexes via its N7 nitrogen atom. 9-Ethylguanine forms adducts with a ruthenium(II) complex via the N7 position of its guanine moiety.
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 879-08-3
- Formula: C7H9N5O
- Molecular Weight:179.18
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
9-Ethylguanine (8 mM) reacts with tetrazolato-bridged dinuclear platinum(II) complexes 3 and 4 to form an identical asymmetric 1:2 complex via Pt(II) migration[1].
9-Ethylguanine complex 3; 1-96 h, room temperature) forms diastereomeric adducts with ruthenium(II) complex 3 via its N7 position within 1 hour at room temperature, with concurrent P-O bond cleavage observed after 24 hours[2].
9-Ethylguanine binds to dichlorido(η6-toluene)(3,5,6-bicyclophosphite-1,2-O-isopropylidene-α-D-glucofuranose)ruthenium(II) via its N7 position, forming diastereomeric adducts within 1 hour at room temperature[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 879-08-3
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Appearance Solid
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Molecular Weight 179.18
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Formula C7H9N5O
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Color White to off-white
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SMILES
O=C1C2=C(N=C(N1)N)N(C=N2)CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 20 mg/mL (111.62 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Uemura M, et al. An in vivo highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex largely circumvents in vitro cisplatin resistance: two linkage isomers yield the same product upon reaction with 9-ethylguanine but exhibit different cytotoxic profiles. Metallomics. 2012;4(7):686-692. [Content Brief]
[2]. Hanif M, et al. Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes. Front Chem. 2013;1:27. Published 2013 Oct 31. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.5810 mL | 27.9049 mL | 55.8098 mL | 139.5245 mL |
| 5 mM | 1.1162 mL | 5.5810 mL | 11.1620 mL | 27.9049 mL | |
| 10 mM | 0.5581 mL | 2.7905 mL | 5.5810 mL | 13.9525 mL | |
| 15 mM | 0.3721 mL | 1.8603 mL | 3.7207 mL | 9.3016 mL | |
| 20 mM | 0.2790 mL | 1.3952 mL | 2.7905 mL | 6.9762 mL | |
| 25 mM | 0.2232 mL | 1.1162 mL | 2.2324 mL | 5.5810 mL | |
| 30 mM | 0.1860 mL | 0.9302 mL | 1.8603 mL | 4.6508 mL | |
| 40 mM | 0.1395 mL | 0.6976 mL | 1.3952 mL | 3.4881 mL | |
| 50 mM | 0.1116 mL | 0.5581 mL | 1.1162 mL | 2.7905 mL | |
| 60 mM | 0.0930 mL | 0.4651 mL | 0.9302 mL | 2.3254 mL | |
| 80 mM | 0.0698 mL | 0.3488 mL | 0.6976 mL | 1.7441 mL | |
| 100 mM | 0.0558 mL | 0.2790 mL | 0.5581 mL | 1.3952 mL |
9-Ethylguanine Related Classifications
HY-126060 Related Classifications
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