1. Anti-infection
  2. Bacterial
    Parasite

ABBV-4083 

Cat. No.: HY-111757
Handling Instructions

ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

For research use only. We do not sell to patients.

ABBV-4083 Chemical Structure

ABBV-4083 Chemical Structure

CAS No. : 1809266-03-2

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity[1].

In Vivo

ABBV-4083 (150 mg/kg, once daily for 14 days) reduces Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) in mice by >99.9% in the recovered female adult worms. Levels of circulating microfilariae declines from ~7 weeks pti and are completely cleared from 12 weeks pti until the end of this study at 16 weeks pti[1].

Animal Model: Female BALB/c mice or female jirds were infected at 6–8 weeks of age with L. sigmodontis larvae through the bites of Ornithonyssus bacoti mites[1].
Dosage: 150 mg/kg
Administration: PO once daily for 14 days started at 14 weeks post infection.
Result: Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) were reduced by >99.9% in the recovered female adult worms.
Starting at ~7 weeks pti, levels of circulating microfilariae declined and were completely cleared from 12 weeks pti until the end of this study at 16 weeks pti.
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9764 mL 4.8818 mL 9.7636 mL
5 mM 0.1953 mL 0.9764 mL 1.9527 mL
10 mM 0.0976 mL 0.4882 mL 0.9764 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

1024.21

Formula

C₅₃H₈₂FNO₁₇

CAS No.

1809266-03-2

SMILES

O[[email protected]@H]1[[email protected]@H](C)O[[email protected]](OC[[email protected]]([[email protected]@H](CC)OC(C[[email protected]]([[email protected]@H]([[email protected]]([[email protected]@H](CC=O)C[[email protected]]2C)O[[email protected]]3([H])O[[email protected]](C)[[email protected]@H](O[[email protected]]4([H])O[[email protected]@H](C)[[email protected]](OCC5=CC=C(F)C=C5)[[email protected]@](O)(C)C4)[[email protected]](N(C)C)[[email protected]]3O)C)O)=O)/C=C(C)/C=C/C2=O)([H])[[email protected]](OC)[[email protected]@H]1OC

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
ABBV-4083
Cat. No.:
HY-111757
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ABBV-4083

Cat. No.: HY-111757