ABBV-4083

Cat. No.: HY-111757: Data Sheet
SDS
Handling Instructions
FAQs
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ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

For research use only. We do not sell to patients.

ABBV-4083 Chemical Structure

CAS No. : 1809266-03-2

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1 mg		Ask For Quote & Lead Time
5 mg		Ask For Quote & Lead Time
10 mg		Ask For Quote & Lead Time

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Description

ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity^[1].

In Vivo

ABBV-4083 (150 mg/kg, once daily for 14 days) reduces Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) in mice by >99.9% in the recovered female adult worms. Levels of circulating microfilariae declines from ~7 weeks pti and are completely cleared from 12 weeks pti until the end of this study at 16 weeks pti^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c mice or female jirds were infected at 6–8 weeks of age with L. sigmodontis larvae through the bites of Ornithonyssus bacoti mites^[1].
Dosage:	150 mg/kg.
Administration:	PO once daily for 14 days started at 14 weeks post infection (pti).
Result:	Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) were reduced by >99.9% in the recovered female adult worms. Starting at ~7 weeks pti, levels of circulating microfilariae declined and were completely cleared from 12 weeks pti until the end of this study at 16 weeks pti.

Clinical Trial

Molecular Weight

1024.21

Formula

C₅₃H₈₂FNO₁₇

CAS No.

1809266-03-2

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@H](C)O[C@](OC[C@H]([C@@H](CC)OC(C[C@H]([C@@H]([C@H]([C@@H](CC=O)C[C@H]2C)O[C@]3([H])O[C@H](C)[C@@H](O[C@]4([H])O[C@@H](C)[C@H](OCC5=CC=C(F)C=C5)[C@@](O)(C)C4)[C@H](N(C)C)[C@H]3O)C)O)=O)/C=C(C)/C=C/C2=O)([H])[C@H](OC)[C@@H]1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (97.64 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9764 mL	4.8818 mL	9.7636 mL
5 mM	0.1953 mL	0.9764 mL	1.9527 mL
10 mM	0.0976 mL	0.4882 mL	0.9764 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (275 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. von Geldern TW, et al. Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity. PLoS Negl Trop Dis. 2019 Feb 28;13(2):e0007159. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9764 mL	4.8818 mL	9.7636 mL	24.4091 mL
	5 mM	0.1953 mL	0.9764 mL	1.9527 mL	4.8818 mL
	10 mM	0.0976 mL	0.4882 mL	0.9764 mL	2.4409 mL
	15 mM	0.0651 mL	0.3255 mL	0.6509 mL	1.6273 mL
	20 mM	0.0488 mL	0.2441 mL	0.4882 mL	1.2205 mL
	25 mM	0.0391 mL	0.1953 mL	0.3905 mL	0.9764 mL
	30 mM	0.0325 mL	0.1627 mL	0.3255 mL	0.8136 mL
	40 mM	0.0244 mL	0.1220 mL	0.2441 mL	0.6102 mL
	50 mM	0.0195 mL	0.0976 mL	0.1953 mL	0.4882 mL
	60 mM	0.0163 mL	0.0814 mL	0.1627 mL	0.4068 mL
	80 mM	0.0122 mL	0.0610 mL	0.1220 mL	0.3051 mL

ABBV-4083 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABBV-40831809266-03-2ABBV4083ABBV 4083ParasiteInhibitorinhibitorinhibit

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ABBV-4083

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