1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. Arginase
  3. BEC hydrochloride

BEC hydrochloride 

Cat. No.: HY-19548A Purity: >98.0%
Handling Instructions

BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively.

For research use only. We do not sell to patients.

BEC hydrochloride Chemical Structure

BEC hydrochloride Chemical Structure

CAS No. : 222638-67-7

Size Price Stock Quantity
10 mM * 1 mL in Water USD 121 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
25 mg USD 370 In-stock
Estimated Time of Arrival: December 31
50 mg USD 680 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively[1].

IC50 & Target

Ki: 0.31 μM (BEC hydrochloride, at pH 7.5) and 30 nM (BEC hydrochloride, at pH 9.5)[1]

In Vitro

The X-ray crystal structure of the arginase-BEC complex has been determined at 2.3 Å resolution from crystals perfectly twinned by hemihedry. The structure of the complex reveals that the boronic acid moiety undergoes nucleophilic attack by metal-bridging hydroxide ion to yield a tetrahedral boronate anion that bridges the binuclear manganese cluster, thereby mimicking the tetrahedral intermediate (and its flanking transition states) in the arginine hydrolysis reaction[2].

In Vivo

Administration of the arginase inhibitor BEC decreases arginase activity and causes alterations in NO homeostasis, which are reflected by increases in S-nitrosylated and nitrated proteins in the lungs from inflamed mice. BEC enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and leads to further increases in airways hyperresponsiveness[3].

Molecular Weight

229.49

Formula

C₅H₁₃BClNO₄S

CAS No.

222638-67-7

SMILES

N[[email protected]@H](CSCCB(O)O)C(O)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 35 mg/mL (152.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3575 mL 21.7874 mL 43.5749 mL
5 mM 0.8715 mL 4.3575 mL 8.7150 mL
10 mM 0.4357 mL 2.1787 mL 4.3575 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

BECArginaseArginase-IINONF-κBinflammationmetaplasiaCCL20hyperresponsivenessInhibitorinhibitorinhibit

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Product name:
BEC hydrochloride
Cat. No.:
HY-19548A
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