1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Broflanilide

Broflanilide 

Cat. No.: HY-108689
Handling Instructions

Broflanilide is a potential insecticide and metabolized to Desmethyl-Broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA Receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM.

For research use only. We do not sell to patients.

Broflanilide Chemical Structure

Broflanilide Chemical Structure

CAS No. : 1207727-04-5

Size Price Stock Quantity
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 700 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2000 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3000 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Broflanilide is a potential insecticide and metabolized to Desmethyl-Broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA Receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM[1].

In Vitro

Broflanilide is an insecticide and metabolized to desmethyl-broflanilide, which is a potent and selective antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM. Desmethyl-broflanilide shows weak activity against human GABAA α1β2γ2 receptor, the mammalian GABAA α1β3γ2 receptor and human glycine receptor (GlyR) α1β with IC50s of >3 μM, and less potently inhibits GlyR α1-A288Gβ and GlyR α1-A288G (IC50s, 0.706, 0.149 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

663.28

Formula

C₂₅H₁₄BrF₁₁N₂O₂

CAS No.

1207727-04-5

SMILES

FC(F)(F)C(F)(C1=CC(C(F)(F)F)=C(NC(C2=C(C(N(C)C(C3=CC=CC=C3)=O)=CC=C2)F)=O)C(Br)=C1)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (376.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5077 mL 7.5383 mL 15.0766 mL
5 mM 0.3015 mL 1.5077 mL 3.0153 mL
10 mM 0.1508 mL 0.7538 mL 1.5077 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (3.14 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.14 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BroflanilideGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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Product Name:
Broflanilide
Cat. No.:
HY-108689
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