1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Broflanilide

Broflanilide 

Cat. No.: HY-108689
Handling Instructions

Broflanilide is a potential insecticide and metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM.

For research use only. We do not sell to patients.

Broflanilide Chemical Structure

Broflanilide Chemical Structure

CAS No. : 1207727-04-5

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Description

Broflanilide is a potential insecticide and metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM.

In Vitro

Broflanilide is an insecticide and metabolized to desmethyl-broflanilide, which is a potent and selective antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM. Desmethyl-broflanilide shows weak activity against human GABAA α1β2γ2 receptor, the mammalian GABAA α1β3γ2 receptor and human glycine receptor (GlyR) α1β with IC50s of >3 μM, and less potently inhibits GlyR α1-A288Gβ and GlyR α1-A288G (IC50s, 0.706, 0.149 μM)[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

663.28

Formula

C₂₅H₁₄BrF₁₁N₂O₂

CAS No.

1207727-04-5

SMILES

FC(F)(F)C(F)(C1=CC(C(F)(F)F)=C(NC(C2=C(C(N(C)C(C3=CC=CC=C3)=O)=CC=C2)F)=O)C(Br)=C1)C(F)(F)F

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Room temperature in continental US; may vary elsewhere

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Product Name:
Broflanilide
Cat. No.:
HY-108689
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Broflanilide

Cat. No.: HY-108689