1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. CP-409092

CP-409092 

Cat. No.: HY-101639
Handling Instructions

CP-409092 is a partial agonist of GABAA receptor, with anti-anxiety activity.

For research use only. We do not sell to patients.

CP-409092 Chemical Structure

CP-409092 Chemical Structure

CAS No. : 194098-25-4

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Description

CP-409092 is a partial agonist of GABAA receptor, with anti-anxiety activity[1].

IC50 & Target

GABAA receptor[1]

In Vivo

The pharmacokinetics of CP-409,092 following single intravenous and oral doses of 4 and 15 mg/kg, respectively, are characterized by high clearance of 169+ or -18 mL/min/kg, a volume of distribution of 8.99+ or -1.46 L/kg, and an oral bioavailability of 2.9%+ or -3%. Following oral administration of 100 mg/kg [14C]CP-409,092, the total recovery is 89.1%+ or -3.2% for male rats and 89.3%+ or -0.58% for female rats[1].

Molecular Weight

297.35

Formula

C₁₇H₁₉N₃O₂

CAS No.

194098-25-4

SMILES

O=C(C1=CNC2=C1C(CCC2)=O)NC3=CC=C(CNC)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (140.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3630 mL 16.8152 mL 33.6304 mL
5 mM 0.6726 mL 3.3630 mL 6.7261 mL
10 mM 0.3363 mL 1.6815 mL 3.3630 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.00 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CP-409092CP409092CP 409092GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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Product name:
CP-409092
Cat. No.:
HY-101639
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