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Pictilisib dimethanesulfonate

(Synonyms: GDC-0941 dimethanesulfonate ; GDC-0941 (2 MeSO3H salt))
68 Cited Publications
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Based on 68 publication(s) in Google Scholar

Pictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).

For research use only. We do not sell to patients.

  • Purity: 99.72%
  • CAS No.: 957054-33-0
  • Formula: C25H35N7O9S4
  • Molecular Weight:705.85
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Pictilisib dimethanesulfonate Chemical Structure
    Pictilisib dimethanesulfonate Chemical Structure
  • Experimental Validation Results for Pictilisib dimethanesulfonate
  • Experimental Validation Results for Pictilisib dimethanesulfonate
  • Experimental Validation Results for Pictilisib dimethanesulfonate
  • Experimental Validation Results for Pictilisib dimethanesulfonate
  • Experimental Validation Results for Pictilisib dimethanesulfonate
  • Experimental Validation Results for Pictilisib dimethanesulfonate
  • Experimental Validation Results for Pictilisib dimethanesulfonate
  • Experimental Validation Results for Pictilisib dimethanesulfonate
CAS No.: 957054-33-0
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WBCell Proliferation/Viability Assay
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  • Pictilisib dimethanesulfonate Chemical Structure
    Pictilisib dimethanesulfonate Chemical Structure
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    Pictilisib dimethanesulfonate purchased from MedChemExpress. Usage Cited in: Int J Oncol. 2017 Sep;51(3):823-831. [Abstract]

    Customer Validation
     Protein levels of BRD4, p-AKT and AKT in GDC-0941 treated NOZ cells after 72 h.

  • 1/16

    Pictilisib dimethanesulfonate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2016 Feb 2:7:10438. [Abstract]

    Customer Validation
     Western blot illustrating the effect of PI3K inhibitors on p21 protein levels in MEFs. Cells are treated for 24 hours with the indicated concentrations of the different drugs.

  • 1/16

    Pictilisib dimethanesulfonate purchased from MedChemExpress. Usage Cited in: Oncogene. 2016 Jun 9;35(23):2961-70. [Abstract]

    Customer Validation
     Western blot analysis of p-AKT(T308), p-AKT(S473) and p-ERK in transplanted NIC+PIK3CAH1047R tumors treated as indicated.

  • 1/16

    Pictilisib dimethanesulfonate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 May 31;7(22):32641-51. [Abstract]

    Customer Validation
     The well-established PI3Kδ specific inhibitor, CAL-101, shows similar effects as PI3KD-IN-015 with an EC50 of 2.3 nM against PI3Kδ and over 1000-fold less potent against the other three isoforms. Determination of CAL-101 inhibitory activities against PI3Kα, β, δ and γ in cellular background.

  • 1/16

    Pictilisib dimethanesulfonate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 Aug 16;7(33):53515-53525. [Abstract]

    Customer Validation
     PI3KD/V-IN-01 affects autophagy HeLa cells are treated with different concentrations of PI3KD/V-IN-01, VPS34-IN-1, GDC-0941 or CAL-101 for 16 hours before they are fixed and stained for the autophagy marker LC3B.

  • 1/16

    Pictilisib dimethanesulfonate purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2013 Jul 31;5(196):196ra99. [Abstract]

    Customer Validation
     Sensitivity to GDC-0941 in parental MDA453 and T47D and BYL719-resistant MDA453R and T47DR cells. Protein lysates are isolated after 24 hours of treatment with 1 μM GDC-0941 and probed against the indicated proteins.

  • 1/16

    Pictilisib dimethanesulfonate purchased from MedChemExpress. Usage Cited in: Cell Metab. 2012 Mar 7;15(3):382-94. [Abstract]

    Customer Validation
     Effect of the indicated PI3K inhibitors on pre-brown adipocytes. Cultures are treated with the inhibitors at the indicated concentrations (μM) for 4 h. Protein levels (top) and mRNA levels (bottom) of the indicated proteins and genes, respectively, are analyzed. Assays are performed in triplicate cultures. Values represent mean ± sd, and statistical significance is determined by the two-tailed Student’s t-test. *p<0.05, **p<0.01.

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    Pictilisib dimethanesulfonate purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2012 May;2(5):425-33. [Abstract]

    Customer Validation
     Effects of KIN-193, GDC-0941, PIK-75 and IC87114 on AKT phosphorylation in PTEN-deficient cell lines as indicated. Representative western blots are shown. Bar graphs represent mean ± SD of western blot quantitations of AKTT308 (n=3).

  • Pictilisib dimethanesulfonate