1. GPCR/G Protein
  2. GPCR19
  3. INT-777 R-enantiomer

INT-777 R-enantiomer (Synonyms: S-EMCA R enantiomer)

Cat. No.: HY-15677A Purity: ≥95.0%
Handling Instructions

INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.

For research use only. We do not sell to patients.

INT-777 R-enantiomer Chemical Structure

INT-777 R-enantiomer Chemical Structure

CAS No. : 1198786-98-9

Size Price Stock Quantity
2 mg USD 420 In-stock
Estimated Time of Arrival: December 31
5 mg USD 840 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of INT-777 R-enantiomer:

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Description

INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.

In Vivo

INT-777 (R-enantiomer) is more choleretic than CA (4), but less than INT-777[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

450.65

Formula

C₂₇H₄₆O₅

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (221.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2190 mL 11.0951 mL 22.1902 mL
5 mM 0.4438 mL 2.2190 mL 4.4380 mL
10 mM 0.2219 mL 1.1095 mL 2.2190 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.55 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.55 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.55 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Keywords:

INT-777 R-enantiomerS-EMCA R enantiomerGPCR19G-protein coupled receptor 19Inhibitorinhibitorinhibit

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Product Name:
INT-777 R-enantiomer
Cat. No.:
HY-15677A
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