2. Anti-infection
  3. Bacterial Antibiotic
  4. Imipenem

Imipenem  (Synonyms: N-Formimidoyl thienamycin; MK0787)

Cat. No.: HY-B1369A Purity: 99.89%
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Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections.

For research use only. We do not sell to patients.

CAS No. : 64221-86-9

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Customer Review

Based on 35 publication(s) in Google Scholar

Other Forms of Imipenem:

Imipenem Related Antibodies

Top Publications Citing Use of Products

35 Publications Citing Use of MCE Imipenem

Microbiological Assay
WB
IF
Histological Imaging/Staining

    Imipenem purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2025 May 23:e0024925.  [Abstract]

    Numbers of organisms treated with 16× MIC NITD-916, 8 mg/L RFB or 16 mg/L IPM at 24 and 48 hours were significantly less than the drug-free control.

    Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191.  [Abstract]

    Combination of ATR and IMP effectively inhibits the formation of NETs. After CLP modeling, ATR was administered with Imipenem monohydrate (25 mg/kg, subcutaneously) at 6 and 18 h. The protein levels of Cit-H3 in the lungs were detected by western blot and analyzed by grayscale.

    Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191.  [Abstract]

    Combination of ATR and IMP effectively inhibits the formation of NETs. After CLP modeling, ATR was administered with Imipenem monohydrate (25 mg/kg, subcutaneously) at 6 and 18 h. Co-localization of Cit-H3, MPO and DAPI was observed by fluorescence microscopy and the level of NETs formation was analyzed (n = 4).

    Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191.  [Abstract]

    Combination of ATR and IMP alleviates lung injury by inhibiting NETs. Treatments were administered at 6 and 18 h post-CLP modeling with ATR, Imipenem monohydrate (25 mg/kg, subcutaneously), and DNase I. After 24 h, lung tissues were examined for pulmonary injury and NET expression. HE staining and scoring of lung tissue, scale bar = 100 μm.

    Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191.  [Abstract]

    Combination of ATR and IMP alleviates lung injury by inhibiting NETs. Treatments were administered at 6 and 18 h post-CLP modeling with ATR, Imipenem monohydrate (25 mg/kg, subcutaneously), and DNase I. After 24 h, lung tissues were examined for pulmonary injury and NET expression. Co-localization of Cit-H3, MPO and DAPI in NET was observed using fluorescence microscopy

    Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191.  [Abstract]

    Imipenem monohydrate (1, 5, 10 μM) was pre-treated with neutrophils for 2 h, followed by stimulation with LPS (5 μg/mL) for 4 h. Cit-H3 was detected by western blot.

    Imipenem purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575.

    Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections[1][2][3].

    IC50 & Target

    β-lactam

     

    In Vivo

    Imipenem (MK0787) (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent[3].
    Pharmacokinetic Parameters of Imipenem in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single)[1].

    50
    Drug and dose(mg/kg) Cmax(mg/liter) Tmax(min) AUCtot(mg min/liter) Vz/F(ml/kg) Vss/F (ml/kg) CL/F(ml/min/kg) t1/2(min) MRT(min)
    Imipenem
    8 15 (7.1) 21 (11) 1,470 (777) 648 (330) 721 (343) 6.7 (3) 67 (11) 108 (12)
    16 34 (6) 28 (18) 2,857 (559) 507 (140) 543 (121) 5.8 (1) 60 (9.1) 94 (10)
    32 54 (11) 18 (6.1) 4,895 (635) 516 (75) 566 (83) 6.6 (0.8) 54 (6.5) 86 (11)
    64 69 (37) 15 (9.5) 6,037 (2,976) 547 (274) 617 (308) 7.4 (3.6) 43 (22) 70 (35)

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Neutropenic mouse model of biofilm lung infection[3]
    Dosage: 4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg
    Administration: 4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single
    Result: Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.
    Molecular Weight

    299.35

    Formula

    C12H17N3O4S
    CAS No.
    Appearance

    Solid

    Color

    Off-white to yellow

    SMILES

    O=C(C(N12)=C(SCCNC=N)C[C@]2([H])[C@@H]([C@H](O)C)C1=O)O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 11.67 mg/mL (38.98 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3406 mL 16.7029 mL 33.4057 mL
    5 mM 0.6681 mL 3.3406 mL 6.6811 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.89%

    SDS (393 KB)

    COA (249 KB) HNMR (258 KB) RP-HPLC (253 KB) MS (68 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.3406 mL 16.7029 mL 33.4057 mL 83.5143 mL
    5 mM 0.6681 mL 3.3406 mL 6.6811 mL 16.7029 mL
    10 mM 0.3341 mL 1.6703 mL 3.3406 mL 8.3514 mL
    15 mM 0.2227 mL 1.1135 mL 2.2270 mL 5.5676 mL
    20 mM 0.1670 mL 0.8351 mL 1.6703 mL 4.1757 mL
    25 mM 0.1336 mL 0.6681 mL 1.3362 mL 3.3406 mL
    30 mM 0.1114 mL 0.5568 mL 1.1135 mL 2.7838 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Imipenem Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Imipenem64221-86-9N-Formimidoyl thienamycin MK0787MK0787MK 0787MK-0787BacterialAntibioticantibioticthienamycinbacteriainfectionP. aeruginosaInhibitorinhibitorinhibit

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