1. Anti-infection
  2. Bacterial Antibiotic
  3. Imipenem monohydrate

Imipenem (monohydrate)  (Synonyms: N-Formimidoyl thienamycin (monohydrate); MK0787 (monohydrate); イミペネム一水和物)

製品番号: HY-B1369 純度: 99.83%
COA 取扱説明書

Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections.

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Imipenem monohydrate 構造式

Imipenem (monohydrate) 構造式

CAS 番号 : 74431-23-5

容量 価格(税別) 在庫状況 数量
100 mg USD 66 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 19 publication(s) in Google Scholar

Other Forms of Imipenem monohydrate:

Top Publications Citing Use of Products
  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections[1][2][3].

IC50 & Target

β-lactam

 

体内実験

Imipenem monohydrate (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent[3].
Pharmacokinetic Parameters of Imipenem monohydrate in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single)[1].

50
Drug and dose(mg/kg) Cmax(mg/liter) Tmax(min) AUCtot(mg • min/liter) Vz/F(ml/kg) Vss/F (ml/kg) CL/F(ml/min/kg) t1/2(min) MRT(min)
Imipenem
8 15 (7.1) 21 (11) 1,470 (777) 648 (330) 721 (343) 6.7 (3) 67 (11) 108 (12)
16 34 (6) 28 (18) 2,857 (559) 507 (140) 543 (121) 5.8 (1) 60 (9.1) 94 (10)
32 54 (11) 18 (6.1) 4,895 (635) 516 (75) 566 (83) 6.6 (0.8) 54 (6.5) 86 (11)
64 69 (37) 15 (9.5) 6,037 (2,976) 547 (274) 617 (308) 7.4 (3.6) 43 (22) 70 (35)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Neutropenic mouse model of biofilm lung infection[3]
Dosage: 4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg
Administration: 4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single
Result: Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.
臨床実験
分子量

317.36

分子式

C12H19N3O5S

CAS 番号
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(C(N12)=C(SCCNC=N)C[C@]2([H])[C@@H]([C@H](O)C)C1=O)O.O

Structure Classification
Initial Source

Streptomyces cattleya

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years

*The compound is unstable in solutions, freshly prepared is recommended.

溶剤 & 溶解度
体外: 

H2O : 6.25 mg/mL (19.69 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1510 mL 15.7550 mL 31.5100 mL
5 mM 0.6302 mL 3.1510 mL 6.3020 mL
10 mM 0.3151 mL 1.5755 mL 3.1510 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます:C1V1 = C2V2

濃度 (開始)

C1

×
体積 (開始)

V1

=
濃度 (終了)

C2

×
体積 (終了)

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (31.51 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.83%

参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.1510 mL 15.7550 mL 31.5100 mL 78.7749 mL
5 mM 0.6302 mL 3.1510 mL 6.3020 mL 15.7550 mL
10 mM 0.3151 mL 1.5755 mL 3.1510 mL 7.8775 mL
15 mM 0.2101 mL 1.0503 mL 2.1007 mL 5.2517 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます:C1V1 = C2V2

濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
Imipenem monohydrate
製品番号:
HY-B1369
数量:
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