2. Anti-infection
  3. Bacterial
    Antibiotic
  4. Imipenem monohydrate

Imipenem monohydrate  (Synonyms: N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate)

製品番号: HY-B1369 純度: 98.53%
COA 取扱説明書

Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections.

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Imipenem monohydrate 構造式

Imipenem monohydrate 構造式

CAS 番号 : 74431-23-5

容量 価格（税別） 在庫状況 数量
無料サンプル (0.1 - 0.5 mg)   今すぐ申し込む  
100 mg USD 66 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 8 publication(s) in Google Scholar

Other Forms of Imipenem monohydrate:

Top Publications Citing Use of Products

Antibiotic アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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製品説明

Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections[1][2][3].

IC50 & Target

β-lactam

 

体内実験

Imipenem monohydrate (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent[3].
Pharmacokinetic Parameters of Imipenem monohydrate in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single)[1].

50
Drug and dose(mg/kg) Cmax(mg/liter) Tmax(min) AUCtot(mg • min/liter) Vz/F(ml/kg) Vss/F (ml/kg) CL/F(ml/min/kg) t1/2(min) MRT(min)
Imipenem
8 15 (7.1) 21 (11) 1,470 (777) 648 (330) 721 (343) 6.7 (3) 67 (11) 108 (12)
16 34 (6) 28 (18) 2,857 (559) 507 (140) 543 (121) 5.8 (1) 60 (9.1) 94 (10)
32 54 (11) 18 (6.1) 4,895 (635) 516 (75) 566 (83) 6.6 (0.8) 54 (6.5) 86 (11)
64 69 (37) 15 (9.5) 6,037 (2,976) 547 (274) 617 (308) 7.4 (3.6) 43 (22) 70 (35)

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Neutropenic mouse model of biofilm lung infection[3]
Dosage: 4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg
Administration: 4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single
Result: Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.
臨床実験
分子量

317.36

Appearance

Solid

分子式

C12H19N3O5S
CAS 番号
SMILES

O=C(C(N12)=C(SCCNC=N)C[[email protected]]2([H])[[email protected]@H]([[email protected]](O)C)C1=O)O.O
Structure Classification
Source

Streptomyces cattleya
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years

*The compound is unstable in solutions, freshly prepared is recommended.
溶剤 & 溶解度
体外: 

H2O : 7.14 mg/mL (22.50 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1510 mL 15.7550 mL 31.5100 mL
5 mM 0.6302 mL 3.1510 mL 6.3020 mL
10 mM 0.3151 mL 1.5755 mL 3.1510 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (31.51 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

*All of the co-solvents are available by MCE.
純度とドキュメンテーション

純度: 98.53%

COA (250 KB) HNMR (205 KB) LCMS (111 KB)

取扱説明書 (2659 KB)
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Imipenem74431-23-5N-Formimidoyl thienamycinMK0787MK 0787MK-0787BacterialAntibioticntibioticthienamycinbacteriainfectionP. aeruginosaInhibitorinhibitorinhibit

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製品名:
Imipenem monohydrate
製品番号:
HY-B1369
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