2. Imipenem monohydrate

Imipenem monohydrate  (Synonyms: N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate)

製品番号: HY-B1369 純度: 99.83%
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Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections.

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Imipenem monohydrate 構造式

Imipenem monohydrate 構造式

CAS 番号 : 74431-23-5

容量 価格（税別） 在庫状況 数量
100 mg USD 66 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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Based on 17 publication(s) in Google Scholar

Other Forms of Imipenem monohydrate:

Imipenem monohydrate 関連抗体

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製品説明

Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections[1][2][3].

体内実験

Imipenem monohydrate (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent[3].
Pharmacokinetic Parameters of Imipenem monohydrate in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single)[1].

50
Drug and dose(mg/kg) Cmax(mg/liter) Tmax(min) AUCtot(mg • min/liter) Vz/F(ml/kg) Vss/F (ml/kg) CL/F(ml/min/kg) t1/2(min) MRT(min)
Imipenem
8 15 (7.1) 21 (11) 1,470 (777) 648 (330) 721 (343) 6.7 (3) 67 (11) 108 (12)
16 34 (6) 28 (18) 2,857 (559) 507 (140) 543 (121) 5.8 (1) 60 (9.1) 94 (10)
32 54 (11) 18 (6.1) 4,895 (635) 516 (75) 566 (83) 6.6 (0.8) 54 (6.5) 86 (11)
64 69 (37) 15 (9.5) 6,037 (2,976) 547 (274) 617 (308) 7.4 (3.6) 43 (22) 70 (35)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Neutropenic mouse model of biofilm lung infection[3]
Dosage: 4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg
Administration: 4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single
Result: Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.
臨床実験
分子量

317.36

分子式

C12H19N3O5S
CAS 番号
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(C(N12)=C(SCCNC=N)C[C@]2([H])[C@@H]([C@H](O)C)C1=O)O.O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years

*The compound is unstable in solutions, freshly prepared is recommended.
溶剤 & 溶解度
体外: 

H2O : 6.25 mg/mL (19.69 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1510 mL 15.7550 mL 31.5100 mL
5 mM 0.6302 mL 3.1510 mL 6.3020 mL
10 mM 0.3151 mL 1.5755 mL 3.1510 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (31.51 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.83%

COA (250 KB) HNMR (269 KB) RP-HPLC (263 KB) MS (68 KB)

取扱説明書 (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.1510 mL 15.7550 mL 31.5100 mL 78.7749 mL
5 mM 0.6302 mL 3.1510 mL 6.3020 mL 15.7550 mL
10 mM 0.3151 mL 1.5755 mL 3.1510 mL 7.8775 mL
15 mM 0.2101 mL 1.0503 mL 2.1007 mL 5.2517 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imipenem74431-23-5N-Formimidoyl thienamycinMK0787MK 0787MK-0787Inhibitorinhibitorinhibit

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製品名:
Imipenem monohydrate
製品番号:
HY-B1369
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